摘要
对于已经形成高脂血症的大鼠 ,有氧运动和山楂有一定的治疗作用 ,以有氧运动结合降脂食品山楂的作用效果最好。山楂组大鼠的TC和ApoB水平显著低于高脂对照组 ,有氧运动组大鼠的TG和ApoB水平显著低于高脂饲料组 ,ApoAI水平显著升高。山楂组大鼠肝细胞SOD水平显著升高 ,而MDA水平显著下降。山楂和运动两者都可以下调主动脉壁LDLRmRNA的表达 ,同时上调肝脏LDLR的基因转录和蛋白表达 ,减少脂质在血管壁的沉积 ,促进清除。山楂和运动联合作用组大鼠血浆的TC ,TG ,LDL ,ApoAI和ApoB水平都比高脂组有显著改善 ,抗氧化能力增强 ,脂质沉积减少 ,清除增强 ,提示对高脂血症的治疗应采取多因素协同的方法增强疗效。
Aerobicexerciseandhawthorncouldhelptocurehyperlipidemia Themostpotenttherapeuticeffectsarefoundinhawthorncom binedaerobicexercisegroup PlasmacholesterolandApoBlevelsaresignificantlylowerinhawthorngroupthanthoseinhighfat group.Whileinaerobicexercisegroup,triglycerideandApoBlevelsaresignificantlylowerandApoAIlevelsignificantlyhigh er Hawthornisapotentanti-oxidantandcansignificantlyincreaseliverSODactivitywhilereducetheproductionoflipidperoxide productsMDA Bothhawthornandaerobicexercisecoulddown -regulateLDLRmRNAtranscription Moreover,theLDLRmRNA transcriptionandproteintranslationinliverareupregulated Thusreducethelipiddepositiononarterywallsandincreaselipidclear ance Inhawthorncombineexerciserats,plasmaTC ,TG ,LDL ,ApoBandApoAIlevelsareimprovedsignificantly Furthermore ,thean tioxideactivityofratsinliverareincreasedandlipiddepositiondecreased Thesedataindicatethatthetherapyofhyperlipidemianeeds thecombinedeffortsofvariousmethods
出处
《中国运动医学杂志》
CAS
CSCD
北大核心
2000年第1期29-32,共4页
Chinese Journal of Sports Medicine
基金
国家自然科学基金!39670 797
关键词
山楂
有氧运动
高脂血症
治疗
exercise ,hawthorn ,hyperlipidemia ,LDLR
