摘要
目的 分析最近两年来儿童急性淋巴细胞白血病 (ALL)的临床预后并探讨其免疫学 ,细胞遗传学特征以及原发性多药耐药的发生率。方法 总结 15 4例初治儿童ALL的完全缓解 (CR)率 ,同时运用免疫组织化学、细胞遗传学等方法对白血病细胞的生物学特征进行研究。结果 儿童初治ALL的平均CR率是 94.1% ,显著高于成人 (6 7.8% ) ;免疫分型中 ,同时伴髓系表达者占 18.5 % ,Ph染色体的阳性率是 4.8% ,两组频率均低于成人 ;二倍体的核型异常明显高于成人 ;儿童多药耐药表型的阳性率明显低于成人。结论 儿童ALL具有较为独特的细胞形态学、免疫学及细胞遗传学特征以及较低的原发性多药耐药发生率 ,这可能是儿童ALL预后良好的原因之一。
Objective To analyze the outcome,the immunological and cytogenetic characteristics and the frequency of primary multi drug resistance of childhood acute lymphoblastic leukemia(ALL)in our hospital during the past two years.Method The complete remission(CR) rate of 154 newly diagnosed ALL patients were analysed and the biological features of the leukemic cells were explored by immunochemistry and cytogenetics. Results The CR rate in the ALL children is 94.1% which is significantly higher than that of adult ALL patients(67.8%). Immunophenotype analysis showed that 18.5% of the children expressed myeloid antigens besides lymphoid antigens and 4.8% of them were Ph chromosome positive.Both the figures were lower than that of adult patients.Conclusion Childhood ALL has distinct morphological, immunological and cytogenetic (MIC) features,which might contribute to the good prognosis of the patients.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
2000年第1期14-16,共3页
Chinese Journal of Hematology
关键词
白血病
ALL
预后
免疫分型
染色体
抗药性
Leukemia,lymphoblastic,acute
Prognosis
Immunophenotyping
Chromosome
Drug resistance,multiple
