摘要
微生物发酵法是目前生产L-赖氨酸最主要的方法。L-赖氨酸生物合成存在两个完全不同的途径:二氨基庚二酸途径和α-氨基己二酸途径;分别由不同的酶进行调节,控制L-赖氨酸的合成。笔者概述了L-赖氨酸生产方法、生物合成途径以及合成中关键性酶的调节作用和国内外L-赖氨酸生产菌育种方法的研究进展。
Fermentation was the mainly used method of L-lysine production presently. There were two completely different biosynthesis pathways of L-lysine： heptanedioic acid pathway, and a-amino hexaned- ioic acid pathway. Different enzymes were used to regulate the two pathways and control the synthesis of L-lysine. In this paper, production methods of L-lysine, biosynthetic pathways as well as the regulations of the key enzymes, and the research evolution of the breeding of L-lysine hyper-producer were summa- rized at home and abroad.
出处
《生物加工过程》
CAS
CSCD
2012年第2期73-78,共6页
Chinese Journal of Bioprocess Engineering
基金
国家高技术研究发展计划(863计划)重大项目(2011AA02A205)
关键词
L-赖氨酸
生物合成
酶
调控
育种
L-lysine
biosynthesis
enzyme
regulation
breeding
