摘要
背景:许多疾病和因素都会使伤口久治不愈或延迟愈合,基因疗法和干细胞疗法为慢性难愈创伤的治疗提供了新的技术途径。目的:针对基因疗法和干细胞疗法用于治疗慢性难愈创伤的研究作一综述。方法:以"gene therapy,stem cell therapy和chronic wound"为检索词,检索Medline数据库(1980/2010-12),文献检索语种限制为英语。将近年发表的针对性强的文章纳入研究范围,同一领域的文献则选择近期发表或权威杂志的文章。排除与基因疗法和干细胞疗法相关性不强、陈旧的文献。结合自身的研究经验和纳入排除标准,对查阅到的最新研究成果详细分析并加以总结概括。结果与结论:初次检索到267篇文献,严格按照纳入标准,最终将33篇文献纳入研究。基因疗法和干细胞疗法都是新的治疗方法,其相关理论和技术已经成熟,为慢性难愈创伤的治疗提供了新的技术途径,它们的有效运用有望给慢性难愈创伤带来突破性的治疗效果。
BACKGROUND： A lot of diseases and factors can cause chronic wound or delayed wound healing. Cene theropy and stem cell therapy provide a new way for the treatment of chronic refractory wounds. OBJECTIVE： To make a review of gene therapy and stem cell therapy in chronic wound healing METHODS： A search across the databases of Medline （1980 to 2010-12） was performed, with key words of ＂gene therapy, stem cell therapy, chronic wound＂. The literatures published in recent years with strong directions were included, and studies unrelated to the objective were excluded. Combined with our research experience, latest abroad researches were accessed and summed up. RESULTS AND CONCLUSION： 267 articles were obtained from the preliminary search across the databases, and 33 documents were eventually included in the study. Gene therapy and stem cell therapy, of which theory and technology grow increasingly mature, have supplied two novel techniques to chronic wound healing and may take breakthrough to the treatment of chronic wound healing.
出处
《中国组织工程研究》
CAS
CSCD
2012年第6期1103-1106,共4页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金项目(30670636)
重庆市自然科学基金项目(2006BB5095)~~
