摘要
目的探讨阴沟肠杆菌(ECL)在临床标本中的分布及耐药性,为临床医师合理用药提供科学依据。方法采用微量稀释法对临床送检标本分离的ECL菌株进行药敏试验,分析其耐药性。结果 136株ECL菌株主要分布在重症监护病房(ICU)(37株)、呼吸内科(36株)、肾内科(18株)、血液内科(14株)和神经内科(14株)等科室;主要来源于痰液(75株),占55.1%。ECL对IPM的敏感率为97%;对头孢吡肟、环丙沙星、庆大霉素、左旋氧氟沙星、哌拉西林/他唑巴坦的敏感率在70%～81%,对哌拉西林、妥布霉素的敏感率在60%～70%之间,对头孢他啶、头孢曲松、氨曲南的敏感率在50%～60%,且均呈下降趋势;对氨苄西林、头孢唑啉、氨苄西林/舒巴坦敏感率仅为5.9%、2.2%和27.9%。结论阴沟肠杆菌耐药性已十分严重,临床应根据药敏结果合理使用抗生素。
Objective To investigate the distribution and drug resistance of Enterobacter cloacae（ECL） in nosocomial infections to provide scientific evidence for the clinical use of antibiotics.Methods ECL isolated from clinical specimens was subjected to a broth microdilution test and its drug resistance was analyzed.Results A total of 136 strains of ECL were mainly isolated from the intensive care unit（ICU）（37 strains）,Respiratory Medicine（36 strains）,Renal Medicine（18 strains）,Hematology（14 strains） and Neurology（14 strains）.ECL was mainly isolated from the sputum（about 55.1% of specimens）.Of 15 types of antibiotics,ECL＇s sensitivity to IPM was 97%.ECL＇s sensitivity to FEP,CIP,GEN,LVX,and TZP was about 70%-81%.Its sensitivity to PIP and TOB was about 60%-70%,and this sensitivity is decreasing.Sensitivity to AMP,CAZ,and SAM was only 5.9%,2.2%,and 27.9%.Conclusion ECL is highly drug-resistant.Clinicians should use antibiotics rationally according to the results of drug susceptibility testing.
出处
《中国病原生物学杂志》
CSCD
北大核心
2012年第2期149-151,共3页
Journal of Pathogen Biology
关键词
医院感染
阴沟肠杆菌
分布
耐药性
Nosocomial infections
Enterobacter cloacae
distribution
drug-resistance
