摘要
目的 探讨由羟基磷灰石和左旋聚乳酸复合研制的新型生物活性颈椎椎间融合器在颈椎融合术中不同固定方式的生物力学特性。方法 制备新鲜人颈椎标本6个（尸体均为合法捐赠，由南方医科大学解剖学教研室提供），模拟临床术式行前路c。减压椎间分别植入髂骨、生物活性颈椎椎间融合器和生物活性颈椎椎间融合器加钢板内固定，通过脊柱三维运动实验机测量C。节段的运动范围。结果 生物活性颈椎椎间融合器加钢板固定后稳定性增加，在各个状态的运动范围均明显小于其他各组（P〈0．005）。单纯生物活性颈椎椎间融合器组在后伸状态下运动范围（6．25±0．29）度较正常组（5．76±0．40）度增大，稳定性下降，但差异无统计学意义（P〉0．05）；在除后伸外的其他各种状态下的运动范围均小于髂骨组，较髂骨组稳定，差异有统计学意义（P〈0．005）。结论 新型生物活性颈椎椎间融合器具有良好的生物力学性能，加钢板内固定后各个方向稳定性好，能重建颈椎稳定性。
Methods Iliac crest bone, bioactive cervical fusion cage and bioaetive cervical fusion cage with plate fixation were used for anterior interbody implants after anterior discectomy across C5-6 in six fresh human cervical spine specimens respectively, and the range of motion of the cervical vertebrae interbody fusion were measured through the motional stability test. Results After discectomy, Bioactive Cervical Fusion Cage with plate fixation exhibited a significant increase in stability and a decrease of range of motion in angular motion than others in all motional directions （ P 〈 0. 005 ）. Bioactive cervical fusion cage exhibited a decrease in stability and an increase of range of motion （6.25 ± 0. 29 ） in angular motion than the intact spine （5.76±0.40）in extension, but the difference was not significantly （P 〉 0.05 ）. Bioactive cervical fusion cage exhibited a decrease in angular motion than iliac crest bone and a significant increase in stability in all motional directions except extension （P 〈 0. 005 ）. Conclusions Bioactive cervical fusion cage＇ s biomechanical performance was excellent and bioactive cervical fusion cage with plate fixation was excellent in stability in all motional direction, and could remain initial stability of cervical vertebrae.
出处
《国际外科学杂志》
2012年第3期157-160,F0003,共5页
International Journal of Surgery
基金
广东省医学科研基金（No.A2011634）,韶关市科技计划项目（N0.韶科（卫）2011-13）
关键词
羟基磷灰石类
聚乳酸类
颈椎椎间融合术
钢板内固定
生物力学
Hydroxyapatites
Poly L- lactic acid
Cervical vertebrae iuterbody fusion
Plate fixation
Biomechanics
