摘要
目的分析系统性红斑狼疮(systemic lupus erythematosus,SLE)患者的主要死亡原因,以提高SLE患者生存率。方法收集2000年1月～2011年1月我院确诊的610例SLE中死亡25例的临床资料,对其病程、死亡原因为存活时间、肾脏病理活检情况、疾病活动度及患者治疗依从性等进行回顾性分析。结果本组病死率为4.09%(25/610),前三位死因为感染12例(48%),神经精神性狼疮5例(20%),心脏猝死3例(12%),平均病程4.9年。死亡因素分析,处于中、重度疾病活动期19例(76%),治疗依从性差19例(76%)。结论增强SLE患者治疗依从性,定期评估疾病活动度,积极防治感染、神经系统和心血管系统并发症,保持病情稳定,是提高患者生存率的关键。
Objective To analyze the main cause of death in patients with systemic lupus erythematosus（SLE） in our district,in order to increase the survival rate.Methods The clinical characteristics of 25 mortality cases from 610 hospitalized patients with SLE were collected during Jan.2000 and Jan.2011.We retrospectively analyzed the duration of SLE,the cause of death,the survival time of SLE,the renal pathologic biopsy in patients with SLE,the disease activity of SLE,and the patient＇s compliance.Results The mortality rate of patients in this group was 4.09%（25/610）,12 patients（48%） died of infection,5 patients（20%） of neuropsychiatric systemic lupus erythematosus,3 patients（12%） of sudden cardiac death,and the mean survival time was 4.9 years.Analysis of the cause of death of 19 patients（76%） showed active SLE,19 patients（76%） showed the low treatment compliance.Conclusion Such measures as to improve the patient＇s compliance,estimate SLE disease activity regularly,prevent infection and neurological complication and cardiovascular complication effectively,and to maintain SLE disease activity stability consistently are key factors in increasing the survival rate of inpatients with SLE.
出处
《临床误诊误治》
2012年第3期92-94,共3页
Clinical Misdiagnosis & Mistherapy
关键词
红斑狼疮
系统性
死亡原因
感染
猝死
心脏
Lupus erythematosus
systemic
Cause of death
Infection
Death
sudden
cardiac
