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高乌甲素术后镇痛对鼾症儿童免疫功能的影响 被引量:2

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摘要 目的探讨高乌甲素用于鼾症儿童术后镇痛效果以及对免疫功能的影响。方法择期全麻下鼾症手术患儿30例,随机分为高乌甲素术后镇痛组(L组)及空白对照组(C组),每组15例,L组于术毕气管导管拔出后静脉滴注高乌甲素0.2 mg/kg,必要时可以追加0.1 mg/kg,C组不给予止痛药,分别于麻醉前30 min(T1)、术后6 h(T2)、24 h(T3)和48 h(T4)4个时点采集外周静脉血,采用放射免疫法测定IgAI、gMI、gG、C3和C4浓度,于术后24、6、、8 h进行疼痛评分,并观察不良反应的发生情况。结果 L组术后2、4、6、8 h疼痛评分明显低于C组(P<0.05);与C组比较,T3~T4时L组IgA浓度升高,T2~T3时IgG浓度升高,T3时IgM浓度升高(P<0.05);C组内,与T1比较,T2~T4时IgA浓度降低,T2~T3时IgMI、gG、C3浓度降低(P<0.05)。结论高乌甲素镇痛能产生良好的镇痛作用,并可改善小儿术后的免疫功能。
出处 《广东医学》 CAS CSCD 北大核心 2012年第5期685-686,共2页 Guangdong Medical Journal
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