摘要
目的探讨t（11；18）（q21；q21）染色体易位对于胃黏膜相关淋巴组织（mucosalassociatedlymphoidtissue，MALT）淋巴瘤预后意义。方法采用回顾性方法对1994年1月至2004年6月间，经术后病理明确诊断的36例MALT淋巴瘤患者进行随访，同时采用间期荧光原位杂交技术检测患者保存的石蜡手术标本有无t（11；18）（q21；q21）染色体易位。结果36例患者中15例检出t（11；18）（q21；q21）染色体易位，阳性率为41．67％；35例随访至2010年3月，总的中位生存期87个月，伴有t（11；18）（q21；q21）染色体易位者的中位生存期为43个月，无t（11；18）（q21；q21）染色体易位者的中位生存期为130个月，两组之间差异有统计学意义（χ^2=29．57，P〈0．01）。结论t（11；18）（q21；q21）染色体易位是MALT淋巴瘤的重要预后因素。
Objective To investigate the prognostic value of t（11;18）（q21;q21）in gastric mucosa- associated lymphoid tissue lymphoma. Methods A cohort of thirty-six gastric mucosa-associated lymphoid tissue lymphoma patients who were pathologically identify diagnosis from January 1994 to June 2004 were followed up retrospectively and studied using fluorescence in situ hybridization（FISH） technique to detect t（11;18） （q21;q21） chromosomal translocation on preservative paraffin specimen. Results Among thirtysix patients, fifteen （41. 67%） were positive for t（11;18） （q21; q21）. All but one were followed up to March 2010, general median survival time （MST） was 87 months. The MST were 43 and 130 months for t（11;18） positive and negative patients, respectively. The MST between these two groups was notably different （χ^2 =29. 57,P〈0. 01）. Conclusion t（11;18） （q21;q21） is important prognostic factor for gastric mucosa-associated lymphoid tissue lymphoma.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
2012年第2期181-183,共3页
Chinese Journal of Medical Genetics
