摘要
目的观察陀螺旋转式钴60立体定向放射系统(陀螺刀)治疗食管癌的近期疗效和急慢性毒副反应。方法采用国产陀螺旋转式钴60立体定向放射系统治疗食管癌120例,全组处方剂量4 200～4 800cGy,中位处方剂量4 500 cGy,350 cGy/次,5次/周,对其近期疗效及急慢性毒副反应进行评价。结果①1年局部控制率为72.50%,1年总生存率为79.25%,1年无瘤生存率为71.18%。②全组患者完全缓解81例(67.50%),部分缓解38例(31.67%),无缓解1例(0.83%),肿瘤总有效率为99.17%。③急性放射性肺损伤0级101例(84.16%),1级19例(15.83%),无2、3、4级发生;晚期放射性肺损伤0级112例(93.33%),1级8例(6.67%),无2、3、4级发生;急性放射性食管损伤0级20例(16.67%),1级98例(81.67%),2级2例(1.7%),无3、4级发生。晚期放射性食管损伤0级101例(84.17%),1级17例(14.17%),2级2例(1.67%),无3、4级发生。结论陀螺刀治疗食管癌初期疗效较好,急慢性放射性食管和肺损伤发生率较低,是一种有效的局部治疗方法,其远期疗效有待进一步观察。
Objective To observe the therapeutic efficacy acute and chronic toxicity of cobalt-60 gyro rotating stereotactic radiotherapy system（gyro knife） in the treatment of esophageal cancer.Methods 120 esophageal cancer patients were treated with gyro knife.The prescription doses of the group were 4 200 to 4 800 cGy and the median prescribed dose was 4 500 cGy.The dose was delivered at 350 cGy each time for 5 times a week.The efficacy and acute and chronic toxicity side effects were evaluated.Results ①1-year local control rate was 72.50%.1-year overall survival rate was 79.25%.And 1-year survival rate was 71.18%.② The treatment achieved complete remission in 81 patients（67.50%）,partial remission in 38 cases（31.67%） and no relief in 1 case,with overall effective rate of 99.17%.③ Grade 0 acute radiation-induced lung injury occurred in 101 cases（84.16%） and grade 1 injury occurred in 19 cases（15.83%）,with no reports of grade 2,3 or 4-level acute lung injury;grade 0 late radiation-induced lung injury occurred in 112 cases（93.33%） and grade 1 injury occurred in 8 cases（6.67%）,with no reports of grade 2,3 or 4 late lung injury;grade 0 acute radiation-induced esophageal injury occurred in 20 cases（16.67%）,grade 1 injury occurred in 98 cases（81.67%） and grade 2 injury occurred in 2 cases（1.7%）,with no reports of grade 3 or 4 injuries： late radiation-induced esophageal injury occurred in grade 0 was 101 cases（84.17%）,grade 1 injury occurred in 17 cases（14.17%）,grade 2 injury occurred in 2 cases（1.67%）,with no reports of grade 3 and 4 injury.Conclusion Gyro knife is an effective treatment for early esophageal cancer with low incidence of acute and chronic radiation-induced esophageal and lung injury.it is also an effective local treatment.However its long-term efficacy remains to be investigated.
出处
《中国医药导报》
CAS
2012年第9期54-56,共3页
China Medical Herald
基金
河北省保定市科学技术研究与发展计划(10ZF089)
关键词
食管癌
陀螺刀
疗效
预后
Esophageal cancer
Gyro knife
Efficacy
Prognosis
