摘要
采用高效毛细管电泳安培法对扑热息痛及其水解物对氨基酚的测定进行了研究。 优化选择了工作电极、检测电位、缓冲溶液浓度等实验参数， 并探讨了进样时间与峰电流的关系。 结果表明： 在优化的实验条件下扑热息痛和对氨基酚在６ ｍｉｎ 内可以得到较好的分离， 检出限分别为０ ．５ μｍｏｌ／Ｌ 和１ ．０ μｍｏｌ／ Ｌ。该法适合药物生产过程的质量控制和临床检测。
A method for separation and determination of acetaminophen and p _ aminophenol by high _ performance capillary electrophoresis-amperometric detection with a microcarbon paste electrode is described. The effects of electrode, detection potential and buffer concentration were extensively investigated. The results showed that acetaminophen and p _ aminophenol were eluted in 6 min with satisfactory separation and the detection limits were 0.5 and 1.0 μmol/L, respectively.
出处
《分析测试学报》
CAS
CSCD
2000年第1期13-15,共3页
Journal of Instrumental Analysis
基金
国家自然科学基金!资助项目(29675033)
关键词
高效毛细管电泳
扑热息痛
对氨基酚
药物分析
High _ performance capillary electrophoresis
Amperometric detection
Carbon paste electrode
Acetaminophen, p _ Aminophenol
