摘要
The optical stability of chiral 2-hydroxy-2-phenylacetic acid in electron ionization mass spectrometry(EIMS) process has been detected directly by deuterium labelling technique. From the EI mass spectrum of deuterated 2-hydroxy-2-phenylacetic acid, the major characteristic fragment ion at m/z 108(the capture of the carbonyl group) and the corresponding isotopic ion(13C) at m/z 109 can be observed, and the ratio of m/z=109 to m/z=108 is about 8%(the calculated value is 7.8%). As enolization of deuterated 2-hydroxy-2-phenylacetic acid in mass spectrometry can yield the characteristic fragment ion at m/z 109 and results in much higher ratio of 109/108 than 8%; this study shows that no enolization takes place during the EI-MS process of 2-hydroxy-2-phenylacetic acid. This results can be concluded that these compounds are optically stable in the process of instantaneous vaporization at high temperature and electron impact ionization.
The optical stability of chiral 2-hydroxy-2-phenylacetic acid in electron ionization mass spectrometry(EIMS) process has been detected directly by deuterium labelling technique. From the EI mass spectrum of deuterated 2-hydroxy-2-phenylacetic acid, the major characteristic fragment ion at m/z 108(the capture of the carbonyl group) and the corresponding isotopic ion(13C) at m/z 109 can be observed, and the ratio of m/z=109 to m/z=108 is about 8%(the calculated value is 7.8%). As enolization of deuterated 2-hydroxy-2-phenylacetic acid in mass spectrometry can yield the characteristic fragment ion at m/z 109 and results in much higher ratio of 109/108 than 8%; this study shows that no enolization takes place during the EI-MS process of 2-hydroxy-2-phenylacetic acid. This results can be concluded that these compounds are optically stable in the process of instantaneous vaporization at high temperature and electron impact ionization.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2000年第1期88-90,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金! (批准号 :2 980 50 0 2 )资助
关键词
手性化合物
光学稳定性分析
质谱过程
Chiral compounds
2-Hydroxy-2-phenylacetic acid
Detection of the optical stability
EI-MS process
