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雌激素与脑缺血 被引量:8

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摘要 雌激素对脑缺血损害具有神经保护作用 ,其作用机制可有以下几个方面 :(1)扩张血管 ,增加局部脑血流量 ,减轻脑缺血损害 ;(2 )改善脑缺血时神经细胞胞突结合的紧密性 ,防止神经细胞缺失 ;(3)抑制β 淀粉样变性 ,减轻脑缺血时神经细胞损伤。因此 ,雌激素对预防和治疗缺血性脑损害有广泛的应用前景。
出处 《国外医学(脑血管疾病分册)》 2000年第1期6-8,共3页 Foreign Medical Sciences Cerebrovascular Diseases
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  • 1Green PS,Gridley KE,Simpkins JW.Estradiol protects against betaamyloid ( 25-35 )-induced toxicity in SK-N-SH human neuroblastoma cells[].Neuroscience Letters.1996
  • 2Honjo H,Tanaka K,Kashiwagi T,et al.Senile dementia-Alzheimer’s type and estrogen[].Hormone and Metabolic Research.1995
  • 3Kimura D.Estrogen replacement therapy may protect against intellectual decline in postmenopausal women[].Hormones and Behavior.1995
  • 4Behl C,Skutella T,Lezoualc’h F,et al.Neuroprotection against oxidative stress by estrogens: structure-activity relationship[].Molecular Pharmacology.1997
  • 5Shi J,Panickar KS,Yang SH,et al.Estrogen attenuates over-expression of beta-amyloid precursor protein messenger RNA in an animal model of focal ischemia[].Brain Research.1998
  • 6Tomirnoto H,Akiguch I,Wakita H,et al.Ultrastructural localization of APP in the normal and postischemic gerbil brain[].Brain Research.1995
  • 7Zhang YQ Shi J,Rajakumar G,et al.Effects of gender and estradiol treatment on focal brain ischemia[].Brain Research.1998
  • 8Kondo Y,Suzuki K,Sakuma Y.Estrogen alleviates cognitive dysfunction following transient brain ischemia in ovariectomized gerbils[].Neuroscience Letters.1997
  • 9Dubal DB,Kashon ML,Pettigrew LC,et al.Estradiol protects against ischemic injury[].Journal of Cerebral Blood Flow and Metabolism.1998
  • 10Toung TJ,Traystman RJ,Hurn PD.Estrogen-mediated neuroprotection after experimental stroke in male rats[].Stroke.1998

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