中性粒细胞弹性蛋白酶在慢性阻塞性肺疾病发病中的作用被引量：9

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摘要目的:探讨中性粒细胞弹性蛋白酶(NE)和α1-抗胰蛋白酶(α1-AT)在慢性阻塞性肺病(COPD)发病中的作用及其相互关系。方法:收集COPD患者104例,其中急性发作期(发作组)53例、稳定期(稳定组)51例;健康查体者(对照组)50例,测定并比较3组血常规和血清NE、α1-AT含量及肺功能指标。结果:3组白细胞(WBC)、中性粒细胞比例(GRA)及NE差别均有统计学意义(P<0.01),均是发作组>稳定组>对照组,发作组与稳定组的α1-AT差别无统计学意义。COPD患者血清α1-AT与NE水平呈正相关(r=0.416,t=3.861,P<0.01)。COPD稳定期患者血清α1-AT水平与残气量/肺总量(36.49±7.23)%呈负相关(r=-0.508,t=4.212,P<0.01),而与第1秒用力呼气容积占预计值的百分比(68.63±10.39)%无明显相关性(r=0.268,t=1.987,P>0.05)。结论:COPD急性发作期NE水平升高、α1-AT水平相对不足是造成肺部炎症的重要原因。

作者骆元正肖玉艳赵玲珑王丽敏

机构地区天津市公安医院呼吸内科

出处《天津医药》 CAS 北大核心 2012年第4期391-392,共2页 Tianjin Medical Journal

关键词肺疾病慢性阻塞性白细胞弹性蛋白酶 Α1抗胰蛋白酶治疗

分类号 R691.3 [医药卫生—泌尿科学]

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参考文献9

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