摘要
目的观察益气养阴方对气阴两虚型鼻咽癌患者生存质量的影响。方法将已经确诊为鼻咽癌气阴两虚型患者60例按1∶1随机分为实验组与对照组。每组30例。对照组给予标准治疗;实验组在标准治疗的基础上加用益气养阴方(黄芪、太子参、绞股蓝、茯苓、山药、薏苡仁、白芍、白芨、天花粉、荷叶、升麻、炙甘草)治疗。参考EORTCQLQ-C30并结合鼻咽癌的相关症状,制定"鼻咽癌患者生存质量调查表",对患者治疗前后的生活质量进行评分。结果实验组、对照组在情绪和记忆功能方面评分分别为(14.10±2.28)、(15.87±2.45),两者比较有统计学差异(P=0.005<0.05);实验组在放疗相关症状方面评分为(24.07±2.00),低于对照组(26.23±2.00)(P=0.000);实验组在口干、食欲差、呕吐程度、体重下降程度方面的评分低于对照组,且两组比较有统计学差异(P值分别为0.011、0.015、0.000、0.013),其中呕吐程度方面,两者比较有显著性差异(P=0.000<0.05);在张口困难、进食吞咽困难、颈部皮肤损伤、声音嘶哑等4个方面,两组比较无明显差异(P值分别为0.638、0.300、0.848、0.859);总体结果表明,鼻咽癌放疗患者短期生存质量的评分由高至低依次为:进食吞咽困难、呕吐、口干、食欲差、体重下降程度、颈部皮肤损伤、张口困难、声音嘶哑。结论益气养阴方能够改善气阴两虚型鼻咽癌患者放疗的生存质量,尤其是放疗过程中所产生的不良反应,如口干、食欲差、呕吐程度、体重下降程度等方面。
Objective To observe the effects of Yi Qi Yang Yin prescription on the quality of life of Syndrome qi and yin deficiency of nasopharyngeal.Methods 60 cases of the patients with NPC in Tipi qi and yin deficiency.Dividing these cases into experimental group and control group stochastically,the two groups both have 30 cases.The experimental group was treated with Yi Qi Yang Yin prescription plus standard treatment,the control group with standard treatment.A questionnaire was designed according to EORTC QLQ-C30 and the related symptoms and side effects of NPC,to compare the marks of QOL between the groups on the time past-treatment.Results In experimental group and control group,the marks of affective cognitive domain were（14.10±2.28）and（15.87±2.45）（P=0.005）;and the marks of disease and treatment-related symptoms were（24.07±2.00）and（26.23±2.00）（P=0.000）;The marks were significantly different in xerostomia、appetite、vomit、lose weight（P0.05）.Conclusion Yi Qi Yang Yin prescription could relieve some acute radiation injury,such as xerostomia,appetite,vomit and weight loss.
出处
《实用癌症杂志》
2012年第2期155-157,173,共4页
The Practical Journal of Cancer
基金
福建省卫生厅资助项目(wzy0907)
关键词
益气养阴方
鼻咽癌
急性放射损伤
生存质量
Tradiation Chinese medicine
Nasopharyngeal
Actue radiation injury
Quality of survival
