摘要
目的:总结PI3K/Akt/mTOR信号通路靶向治疗在乳腺癌中的研究进展。方法:以"PI3K/Akt/mTOR、信号通路和乳腺癌"等为关键词,检索2000-01-2011-06PubMed、Ovid和Springer等数据库的相关文献。纳入标准:1)关于PI3K/Akt/mTOR信号通路的组成、功能特点;2)PI3K/Akt/mTOR信号通路与乳腺癌的关系研究;3)以PI3K/Akt/mTOR信号通路中关键分子为靶点的乳腺癌治疗。根据纳入标准,符合分析的文献40篇。结果:信号转导通路的异常是肿瘤发生、发展的重要步骤,PI3K/Akt/mTOR信号通路与人类多种肿瘤密切相关,其在肿瘤细胞的增殖、存活、抵抗凋亡、血管发生和转移以及对放化疗抵抗中发挥了重要作用。乳腺癌中常见PI3K/Akt/mTOR信号通路的异常激活,以此通路为靶点的药物已成为乳腺癌治疗的研究热点。结论:靶向PI3K/Akt/mTOR通路中关键分子的众多药物在乳腺癌开展了一系列相关的临床试验研究,一部分显示出较好的安全性和有效性。随着对PI3K/Akt/mTOR通路的分子生物学机制的深入研究,期待靶向此通路的抑制剂将会在乳腺癌治疗中发挥巨大的作用,进一步提高乳腺癌患者的疗效和改善预后。
OBJECTIVE： To review the targeted therapy on PI3K/Akt/mTOR signaling pathway in breast cancer. METHODS ： The following keywords ： PI3K/Akt/mTOR, signaling pathway, breast cancer were nsed, and the database of PubMed, Ovid, Springer were searched; The limited time was 2000--2010. Enrolled criteria： the composition and function of the signaling pathway, the aberation of it in breast cancer and targeted targeted therapies in clinical trials. Totally 167 related literatures were searched. Finally,40 literatures were included in this review. RESULTS： The abnormal acti- vation of signal transduction pathways plays key roles in the occurrence and development of tumor. The PI3K/Akt/ mTOR pathway is associated with multiple tumors, and it plays important roles in tumor cell proliferation, survival, antiapoptosis,angiogenesis, metabolism, resistance to radiation and chemotherapy. The activation of the signal pathway is al- ways occurred in breast cancer,the drugs have become hot spots. CONCLUSION： There are many drugs targeted the key molecules of PI3K/Akt/mTOR pathway for breast cancer in clinical trials, some studies have made promising results. With the fututher molecular biology mechanism research we expect to provide reference for studying breast cancer thera- pies which targeted the PI3K/Akt/mTOR pathway, and shows good safety and effectiveness and to improve effectiveness and prognosis of breast cancer patients.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2012年第3期230-234,共5页
Chinese Journal of Cancer Prevention and Treatment
基金
国家自然科学基金(81072816)
关键词
乳腺肿瘤
靶向治疗
PI3K/AKT/MTOR
综述文献
PI3K/Akt/mTOR
signaling pathway
breast cancer were nsed
and the database of PubMed
Ovid
Springer were searched
The limited time was 2000-2010.Enrolled criteria： the composition and function of the signaling pathway
the aberation of it in breast cancer and targeted targeted therapies in clinical trials.Totally 167 related literatures were searched.Finally
40 literatures were included in this review.RESULTS： The abnormal activation of signal transduction pathways plays key roles in the occurrence and development of tumor.The PI3K/Akt/mTOR pathway is associated with multiple tumors
and it plays important roles in tumor cell proliferation
survival
anti-apoptosis
angiogenesis
metabolism
resistance to radiation and chemotherapy.The activation of the signal pathway is always occurred in breast cancer
the drugs have become hot spots.CONCLUSION： There are many drugs targeted the key molecules of PI3K/Akt/mTOR pathway for breast cancer in clinical trials
some studies have made promising results.With the fututher molecular biology mechanism research we expect to provide reference for studying breast cancer therapies which targeted the PI3K/Akt/mTOR pathway
and shows good safety and effectiveness and to improve effectiveness and prognosis of breast cancer patients. Key words： breast neoplasms
targeted therapy
PI3K/Akt/mTOR
review literature
