摘要
目的:探讨直肠癌组织中血管内皮细胞生长因子-C(VEGF-C)与CEA、Survivin表达的关系及其对直肠癌临床病理特征和预后的判定价值。方法:应用SP免疫组织化学方法检测VEGF-C、CEA和Survivin 3种蛋白在82例直肠癌组织及30例癌旁正常组织中的表达,分析它们与直肠癌病理学特征的关系,以及VEGF-C与CEA、Survivin的相关性。结果:直肠癌组织中VEGF-C与CEA、Survivin阳性表达率分别为45.1%、56.1%和47.6%。癌旁组织中Survivin蛋白表达率为5.0%,VEGF-C和CEA蛋白阳性表达率分别为10.5%和14.0%;直肠癌组织中VEGF-C表达与CEA表达呈正相关(r=0.287,P=0.024),与Survivin表达呈正相关,r=0.320,P=0.018。VEGF-C与CEA、Survivin的表达与TNM分期差异均有统计学意义(P<0.05),与年龄、性别、肿块大小及病理分型差异均无统计学意义,P>0.05。结论:VEGF-C与CEA、Survivin在直肠癌患者中高表达;其均与直肠癌的浸润、转移有关,三者联合检测可用于直肠癌的病期程度和预后判断的参考,可能对直肠癌的预后评估有一定的临床意义。
OBJECTIVE： To investigate the correlation of the expression of VEGF-C with CEA and Survivin in rectal cancer,and their values for determining the clinicopathological characteristics and prognosis of rectal cancer.METHODS： Immunohistochemical SP stainingwasused to detect the expressions of VEGF-C,CEA and Survivin proteins in 82 rectal cancer tissues and 30 adjacent normal tissues.Their relationship with the pathological characteristics of rectal cancer was analyzed.The correlation of abnormal expressions of VEGF-C and CEA and Survivin was analyzed.RESULTS： In rectal cancer tissues,the positive rate of VEGF-C,CEA and Survivin protein were 45.1%,56.1% and 47.6%,respectively.In tissues adjacent to cancer the positive rates of VEGF-C,CEA and Survivin expression were 10.5%,14.0% and 5.0%,respectively.The expression of VEGF-C had positive correlation with expression of CEA（r=0.287,P=0.024） and Survivin（r=0.320,P=0.018）.The expression of VEGF-C,CEA and Survivin was associated with TNM staging（P0.05）.However,they all no correlated with ages,gender,tumor size and pathological classification（P0.05）.CONCLUSIONS： VEGF-C and CEA,Survivin is highly expressed in rectal cancer patients,and they are all corelated with cancer invasion and metastasis.The three joint detection can be used for rectal cancer stage of disease extent and prognosis of reference.The prognosis of rectal cancer may have some clinical significance.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2012年第4期272-275,共4页
Chinese Journal of Cancer Prevention and Treatment
