摘要
目的了解该地区孕妇ABO血型抗A(B)IgG抗体效价异常率,分析其在新生儿溶血病(HDN)中的意义。方法采用微柱凝胶法对4000例孕周20周以上、O型血孕妇(丈夫为非O型血)进行血清抗A(B)IgG抗体效价检测;对抗体效价大于1:64者所分娩新生儿进行HDN试验检测,分析抗体效价与HDN发病率的关系。结果 4000例孕妇中,血清抗A(B)IgG抗体效价大于1:64者有432例,异常率为10.8%(432/4000);295例血清抗A(B)IgG抗体效价大于1:64者所分娩的新生儿中,HDN发病率为53.9%(159/295)。结论随着血清IgG抗A(B)效价增高,HDN发病率也增高;产前抗体效价检测是可用于判断HDN发病风险的筛查指标。
Objective To analyze the abnormal rate of ABO blood group anti-A（B） IgG antibody titer in gravida in this area and its relationship with hemolytic disease of the newborn（HDN）.Methods Microcolumn gel method was performed for the detection of antibody titer in 4 000 cases of gravidas.Neonatus,delivered by gravida with antibody titer more than 1：64,were detected with HDN tests.Relationship between antibody titer and the incidence rate of HDN was analyzed.Results The abnormal rate of antibody titer was 10.8%（432/4 000）.In neonatus,delivered by gravida with abnormal antibody titer,the incidence rate of HDN was 53.9%（159/295）.Conclusion The incidence rate of HND could increase with the increasing of the titer of anti-A（B） antibody in gravida.Detection of antibody titer before delivery might be an effective indicator for the screening of HDN.
出处
《国际检验医学杂志》
CAS
2012年第6期719-719,721,共2页
International Journal of Laboratory Medicine
关键词
溶血
ABO血型系统
母婴血型不合
婴儿
新生
hemolysis
ABO blood group system
maternal-fetal blood group incompatibility
infant
newborn
