摘要
目的系统评价他汀类药物对糖尿病性骨质疏松患者骨钙素和骨密度的影响。方法计算机检索Cochrane、pubmed、EMbase、CBM、CNKI,检索时间为从建库至2011年8月。评价质量及提取资料后,采用RevMan 5.1软件对数据进行Meta分析。结果纳入随机对照试验的文献数7篇,共453例,Meta结果显示,对骨钙素的影响[MD=0.26,95%CI(0.06,0.46)],腰椎骨密度的影响[MD=0.22,95%CI(0.05,0.40)],股骨颈骨密度的影响[MD=0.04,95%CI(-0.05,0.13)],Wards三角区骨密度的影响[MD=0.06,95%CI(0.02,0.09)],大转子骨密度的影响[MD=0.03,95%CI(-0.00,0.07)],髋骨骨密度的影响[MD=0.02,95%CI(-0.02,0.07)]。结论他汀类药物对糖尿病性骨质疏松患者的治疗还是有一定的疗效,但由于文献质量方面不太理想,尚需更多高质量的随机对照试验提供依据。
Objective To systematically evaluate the effect of statins on bone gla protein（BGP） and bone mineral density（BMD） of diabetic osteoporosis（DOP） patients.Methods PubMed,EMbase,Cochrane,CBM,and CNKI database were researched.The time for research was from the beginning of database establishment to August 2011.The Meta analysis was performed using RevMan 5.1 software after the quantity evaluation and obtaining the materials.Results Seven papers of randomized controlled trial involving 453 patients were included.The influences on BGP,BMD of the lumbar spine,femoral neck,Ward＇s triangle,trochanter,and total hip were showed by Meta-analysis,respectively.Conclusion Statins have definite efficacy for the treatment of DOP.However,due to unsatisfied paper quality,more RCTs with high quality are needed.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2012年第3期263-268,共6页
Chinese Journal of Osteoporosis
基金
广东省自然科学基金(7009932)
