摘要
目的探讨血浆同型半胱氨酸（Hey）水平与肌萎缩侧索硬化症（ALS）间的关系。方法分别检N150例确诊或拟诊的ALS患者和137例年龄、性别匹配的健康体检者的血叶酸，维生素B12和Hcy水平，比较两组间的差异。结果ALS患者血Hey水平较对照组明显增高[（18．47±13．09）μmol／L比（11．91±5．37）μmol／L，P〈0．001]，而血叶酸水平显著降低[（8．39±4．45）μg/L比（10．38±5．01）μg/L，P〈0．001]。logistic回归显示血Hcy水平与ALS相关，是重要的危险因素；同样发现诊断间期（Interval from sympt omonset to diagnosis，ODI）少于19个月的患者较超过19个月的患者血浆Hcy水平明显增高[（20．73±15．79）μmol／L比（16．41±9．73）μmol／L，P=0．035]。结论ALS患者血浆Hcy水平较健康对照明显增高，血Hey水平和诊断间期相关预示血浆Hcy水平可能与病程进展速度有关。
Objective To investigate the relationship between plasma level of homocysteine （Hey） and amyotrophic lateral sclerosis （ALS）. Methods The differences of Hey, Vitamin B12, and folate levels between 150 outpatients with ALS and 137 age and sex matched controls were compared in a cross-sectional study. Results Compared with the healthy controls, patients with ALS had a higher plasma Hey level [ （ 18.47 ±13.09 ）μmol/L vs （ 11.91 ± 5.37 ） μmol/L, P 〈 0. 001 ] and a lower folate level [ （ 8.39 ± 4.45） ng/ml vs （10.38 ±5.01） ng/ml, P〈0.0011. In a logistic regression model using ALS as a dependent variable, plasma level of Hcy was significantly associated with ALS. A trend for higher Hcy levels in patients with shorter interval from symptom onset to diagnosis （ODI） was also found [ Hcy levels （20. 73 ± 15.79） μmol/L with ODI 〈 19 months vs （ 16.41 ± 9.73 ） }xmol/L with ODI ≥ 19 months, P = 0. 035 ]. Conclusions Plasma Hcy level is significantly increased in patients with ALS. The individuals with shorter time to diagnosis present higher Hey level, suggesting that it may associate with the progression pace of ALS.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2012年第4期308-310,共3页
Chinese Journal of Internal Medicine
基金
国家自然科学基金（81030019,30871359）
北京市自然科学基金（7082099,7102161）
首都医学科技发展基金（SF-2009-Ⅲ-34）
关键词
半胱氨酸
肌萎缩侧索硬化
Cysteine
Amyotrophic lateral sclerosis
