摘要
目的探讨精神分裂症患者心理旋转的脑电生理机制,完善与精神分裂症患者在空间能力方面的事件相关电位(event-related potentials,ERP)的功能联系。方法对来自解放军第三医院的30例精神分裂症患者和28例正常健康人进行心理旋转任务的ERP测定。测量其P300家族成分中P500的潜伏期、波幅及其错误数和反应时。结果与对照组P500[PZ:(493.39±54.00)ms,(5.63±4.22)μv;P3:(495.68±42.00)ms,(6.50±3.76)μv;P4:(478.89±43.42)ms,(4.93±3.67)μv;CZ:(487.11±45.21)ms,(5.34±4.10)μv]相比,患者组合计潜伏期均延迟[PZ:(573.37±45.01)ms,t=3.38;P3:(584.70±43.13)ms,t=2.92;P4:(578.30±41.71)ms,t=-2.30;CZ:(493.39±54.00)ms,t=-2.56],合计波幅均降低[PZ:(3.04±1.32)μv,t=3.26;P3:(4.02±1.52)μv,t=2.80;P4:(2.73±2.00)μv,t=-2.20;CZ:(5.63±4.22)μv,t=-2.43],差异均有统计学意义(P<0.05);区分正镜像时,患者组正像和镜像潜伏期都延迟、波幅都降低,差异均有统计学意义(P<0.05)。结论精神分裂症患者心理旋转能力受损,正镜像受损程度不一致,正镜像加工的电生理机制可能不同,提示可作为临床辅助诊断指标。
Objective To explore the brain electrophysiological mechanism of schizophrenia mental rotation, and to improve the function relation of event-related potentials for schizophrenia in space ability. Methods Testing P500 of P300 family composition potentials when 30 patients with schizophrenia and 28 normal healthy people made the mental rotation tasks, Measuring the incubation period and amplitude of P500, and the wrong number and reaction time. Results Compared with control group P500 composition （PZ： （493.39 ± 54.00）ms, （5.63 ± 4.22）1xv; P3：（495.68-± 42.00）ms, （6.50 ± 3.76）μv; P4：（478.89 ± 43.42）ms, （4.93 ± 3.67）μv; CZ： （487.11 ± 45.21）ms, （5.34 ± 4.10） μv）, when the determining results on normal and mirror image were combined, schizophrenia＇ incubation period was significantly later （PZ： （573.37 ± 45.01）ms, t = 3.38; P3：（584.70 ± 43.13）ms, t = 2.92; P4：（578.30 ±41.71）ms, t = -2.30; CZ： （493.39 ± 54.00）ms, t = -2.56） and volatility was lower （PZ： （3.04 ±1.32）μv,t = 3.26; P3：（4.02 ± 1.52）μv, t = 2.80; P4：（2.73 ±2.00）μv, t = -2.20; CZ： （5.63 ±.22）μv, t = -2.43） with a statistically significant difference （P 〈 0.05）. Distinguishing normal and mirror image, in the patient group, the incubation periods in normal and mirror image were significantly later and volatility were significantly lower with a statistically significant difference （P 〈 0.05）. Conclusion Schizophrenia＇ mental rotation ability is impaired, and extent of the damage is inconsistent between normal and mirror. And hinting the normal and mirror brain electrical and physiological processing mechanism may be different in mental rotation. It can be used as a chnical auxiliary diagnosis index.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2012年第3期160-164,共5页
Chinese Journal of Nervous and Mental Diseases
基金
军队中医药科研专项课题(编号:10ZYX108)
