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少量蛋白尿IgA肾病患者的临床、病理特点分析 被引量:5

Clinicopathological analysis of IgA nephropathy patients with minimal proteinuria
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摘要 目的:总结少量蛋白尿IgA肾病(IgAN)患者的临床病理特点,探讨影响其肾功能减退的可能因素。方法:对412例少量蛋白尿IgAN患者的临床、实验室及病理表现(包括病理半定量检查)进行回顾性对比分析。结果:5年间少量蛋白尿IgAN患者占全部肾活检病例的10.2%。其中,肾功能正常者占87.1%,肾功能异常者占12.9%。肾功能异常组高血压患病率、蛋白尿和血尿酸水平均显著高于肾功能正常组(P<0.01,P<0.05)。肾功能异常组肾小球硬化程度显著重于肾功能正常组(P<0.01),同时肾小管间质病变及血管病变亦较重(P<0.05)。结论:少量蛋白尿IgAN患者的肾功能及病理损伤亦可能较重。蛋白尿、高血压及高尿酸血症均可能影响患者的预后。临床中应积极行肾穿刺,及早发现有治疗价值的病变。 Objective:To study the clinicopathological features of IgA nephrology(IgAN)patients with minimal proteinuria and investigate the risk factors associated with renal injury.Methods:The clinical,laboratory and pathological manifestations of all IgAN patients with minimal proteinuria were retrospectively analyzed and compared.Results:Of all the renal biopsy cases in the past five years,IgAN with minimal proteinuria consisted of 10.2%,359(87.1%)patients had normal renal function and 53(12.9%)patients had abnormal renal function.Higher hypertension,higher level of serum uric acid and more proteinuria were found in cases with renal insufficiency(P0.01,P0.05)compared with those of normal renal function.The glomerular,tubulointerstitial and vascular damage index were more higher in patients with abnormal renal function.Conclusion:Severe renal histological injury and decrease of renal function may be seen in some IgAN patients with minimal proteinuria.Proteinuria,hypertension and serum uric acid effect the prognosis of these patients.Renal biopsy is important in these patients.
出处 《中日友好医院学报》 2012年第2期67-69,73,共4页 Journal of China-Japan Friendship Hospital
关键词 IGA肾病 蛋白尿 临床表现 肾脏病理 IgA nephrology proteinuria clinical manifestations kidney pathology
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参考文献10

  • 1Li Ls,Liu ZH.Epidemiologic data of renal diseases from asingle unit in china:analysis based on 13519 renal biopsies[J].Kidney Int,2004,66(3):920-923.
  • 2Goto M,Wakai K,Kawamura T,et al.A scoring system topredict renal outcome in IgA nephropathy:a nationwide 10year prospective cohort study[J].Nephrol Dial Transplant,2009,24:3068-3074.
  • 3Lee SM,Rao VM,Franklin WA,et al.IgA nephropathy:morphologic predictors of progressive renal disease[J].HumPathol,1982,13:314-322.
  • 4Katafuchi R,Kiyoshi Y,Oh Y,et al.Glomerular score as aprognosticator in IgA nephropathy:its usefulness andlimitation[J].Clin Nephrol,1998,49:1-8.
  • 5Donadio Jv,Grande JP.IgA nephropathy[J].N Engl J Med,2002,347:738-748.
  • 6Szeto CC,Lai FM,To KF,et al.The natural history ofimmunoglobulin A nephropathy among patients withhcmaturia and minimal proteinuria[J].Am J Med,2001,110:434-437.
  • 7张馨,黎磊石,孙骅,鲍浩,陈惠萍,曾彩虹,郑春霞,刘志红.不同类型IgA肾病的流行病学及临床特点分析[J].肾脏病与透析肾移植杂志,2006,15(4):305-310. 被引量:63
  • 8Sturm G,Kollerits B,Neyer U,et al.Uric acid as a riskfactor for progression of non-diabetic chronic kidneydisease?The Mild to Moderate Kidney Disease(MMKD)Study[J].Exp Gerontol,2008,43:347-352.
  • 9Feis DI.Uric acid:a novel mediator and marker of risk inchronic kidney disease?[J].Curr Opin Nephrol Hypertens,2009,18:526-530.
  • 10Coppo R,Cattran D,Roberts Ian SD,et al.The new oxfordclinicopathological classification of IgA nephropathy[J].Prilozi,2010,31:241-248.

二级参考文献15

  • 1沈淑琼,俞雨生.IgA肾病系膜区IgA沉积的机制[J].肾脏病与透析肾移植杂志,2005,14(3):263-267. 被引量:5
  • 2梅洁卉,俞雨生.肾小球血管炎病变在IgA肾病中意义的探讨[J].肾脏病与透析肾移植杂志,2005,14(6):559-563. 被引量:6
  • 3俞雨生.肉眼血尿、大量蛋白尿伴肾功能减退[J].肾脏病与透析肾移植杂志,2005,14(6):578-583. 被引量:1
  • 4Li LS,Liu ZH.Epidemiologic deta of renal diseases from a single unit in China:analysis based on 13,519 renal biopsies.Kidney Int,2004,66 (3):920-923.
  • 5Jonathan Barratt,Iohn Feehally.IgA Nephropathy.J Am Soc Nephrol,2005,16:2088-2097.
  • 6Barratt J,Feehally J.Treatment of IgA nephropathy.Kidney Int,2006,69:1934-1938.
  • 7Cheuk-Chun Szeto,MBCHB,Fernand Mac-Moune Lai,et al.The natural history of immunoglobulin a nephropathy among patients with hematuria and minimal proteinuria.Am J Med,2001,110:434-437.
  • 8Lai KN.Pathogenic IgA in IgA nephropathy:still the blind men and the elephant.Kidney Int,2006,69:1102-1103.
  • 9Akagi H,Kosaka M,Hattori K,et al.Long-term results of tonsllectomy as a treatment for IgA nephropathy.Acta Otolaryngol (Suppl),2004,12:38-42.
  • 10Appel GB,Waldman M.The IgA nephropathy treatment dilemma.Kidney Int,2006,69:1934-1944.

共引文献62

同被引文献53

  • 1罗金国,张传芳,曹泽慧.中西医结合治疗肾病综合征水肿概况[J].辽宁中医杂志,2010,37(S1):198-199. 被引量:11
  • 2陈清萍,江亮,刘剑荣,刘德卿,王稻,曹珊,汤礼萍.贺斯和血浆白蛋白治疗肾病综合征水肿的临床对比研究[J].中国医药指南,2008,6(23):243-245. 被引量:7
  • 3吕继成,张宏,刘刚,江建青,王海燕.IgA肾病呈单纯血尿和(或)轻度蛋白尿临床病理分析[J].中华肾脏病杂志,2004,20(6):418-420. 被引量:46
  • 4Brajae I, Kastelan M, Prpic-Massari L, et al. Melanocyte as a possible key cell in the pathogenesis of psoriasis vulgaris[ J]. Med Hypotheses,2009,73 (2) :254-256.
  • 5Koszik F, Staff G, Selenko-Gebauer N, ct al. Thyroid function in pa- tients with proteinuria[ J ]. Neth Med, 2009, 67 : 153.
  • 6O'Daly JA, Gleason J, Lezama R,et al. Antigens from Leishmania amastigotes inducing clinical remission of psoriatic arthritis [ J ]. Arch Dermatol Res,2011,303 ( 6 ) : 399 -415.
  • 7Kim MJ, McDaid JP, McAdoo SP, et al. Spleen tyrosine kinase is im- portant in the production of proinflammatory cytokines and cell prolifer- ation in human mesangial cells following stimulation with IgAl isolated from IgA nephropathy patients [ J ]. Immunnl, 2012, 189 ( 7 ) : 3751 - 3758.
  • 8Zhou FD, Zhao MH, Zou WZ, et al. The changing spectrum of primary glomerular diseases within 15 years:a survey of 3331 pa- tients in a single Chinese centre. Nephrol Dial Trans - plant, 2009,24 ( 3 ) : 870 - 876.
  • 9Li LS, Liu ZH. Epidemiologic data of renal diseases from a single unit in China: analysis based on 13,519 renal biopsies. Kidney Int,2004,66 ( 3 ) :920 - 923.
  • 10Le W, Liang S, Hu Y, et al. Long - term renal survival and relat- ed risk factors in patients with IgA nephropathy:resuhs from a cohort of l155cases in a Chinese adult population. Nephrol Dial Transplant ,2012,27 (4) : 1479 - 1485.

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