摘要
检测34例白血病患者的血清可溶性白细胞介素2受体(sIL—2R)水平,並分析了sIL—2R与病情变化的相关性。结果显示:1.各组患者的sIL—2R水平明显高于正常(p<0.01);2.sIL-2R水平>2000u/ml的6名患者中有5名在采血后1个月内死亡,余1例亦在1年内死亡;3.患者血清sIL—2R水平与末梢血白细胞总数及单个核细胞数无明显关系。分析表明:sIL—2R测定适用于对急性淋巴细胞性、单核细胞性白血病及淋巴瘤合并白血病的病情监测及预后判断。
Serum soluble IL- 2 receptor (sIL-2R) level of 34 patients with leukemia were measured by ELISA. The sIL- 2 R levels are 296±99u /ml in normal, 660 ±449u /ml in AML, 1323 ±755 u/m in ALL, 1577 ± 759 u /ml in AMML and 1815 ± 858 u /ml in NHL. 5 of 6 patients with 2000u /ml sIL- 2 R died in one month after detection of sIL-2R. There is no apparent relationship between sII -2 R level and mononuclear cells count in peripheral blood. The results suggest that it is possible to be a new parameter for the observation and prognosis estimation to patients with leukemia by detection of sIL-2R.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1990年第5期304-307,共4页
Chinese Journal of Immunology
