摘要
目的测定21个厂家生产的盐酸普萘洛尔片在不同溶出介质中的溶出度,通过溶出曲线来评价药品内在质量。方法在4种溶出介质中,采用桨法进行溶出度试验,使用不同介质中的溶出曲线对结果进行分析和比较。结果与结论各厂家产品溶出行为差别较大,产品质量存在差异。
Objective To detect the dissolution of propranolol hydrochloride tablets from different pharmaceutical factories in 4 different mediums and evaluate the quality by dissolution curves. Methods The dissolution test was carried out with paddle- rotating method. To analyse and compare the results by the dissolution curves in different mediums. Results and Conclusion There was significant dif- ference in dissolution parameters and the quality among the propranolol hydrochloride tablets preparations from different manufactories.
出处
《中国药业》
CAS
2012年第7期15-16,共2页
China Pharmaceuticals
关键词
盐酸普萘洛尔片
溶出度
溶出曲线
紫外分光光度法
Propranolol Hydroehloride Tablets
dissolution
Weibull Equation
UV - spectrophotometry
