摘要
脑胶质瘤是脑内最常见的肿瘤,约占脑肿瘤半数以上,其中以间变型星形细胞瘤和胶质母细胞瘤的恶性程度较高,且具有高复发率和高病死率的特点。临床上的主要治疗方法是在手术治疗基础上辅以放疗和化疗,即使如此肿瘤仍会很快复发。其中胶质母细胞瘤患者一般平均存活仅10~12个月,大多数在确诊后1年半左右死亡[1]。
出处
《中国药物与临床》
CAS
2012年第4期491-493,共3页
Chinese Remedies & Clinics
参考文献4
-
1Salcman M,Scholtz H,Kaplan RS. Long-term survival in patients with malignant astrocytoma[J].Neurosurgery,1994,(02):213-220.
-
2Walker MD,Alexander E Jr,Hunt WE. Evaluation of BC-NU and/or radiotherapy in the treatment of anaplastic gliomas:a cooperative clinical trial[J].Journal of Neurosurgery,1978,(03):333-343.
-
3Medical Research Council Brain Tumor Working Party. Random-ized trial of procarbazine,lomustine,and vincristine in the adju-vant treatment of high-grade astrocytoma:a medical research council trial[J].Journal of Clinical Oncology,2001,(02):509-518.
-
4Stupp R,Hegi ME,Mason WP. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase Ⅲ study:5-year analysis of the EORTC-NCIC trial[J].Lancet Oncology,2009,(05):459-466.
同被引文献24
-
1王煜,雷霆,牛洪泉,董震,董芳永,柳再明,薛德麟.树突状细胞瘤内注射和化疗联合治疗脑胶质瘤的实验研究[J].中华神经外科杂志,2006,22(3):184-186. 被引量:11
-
2Bauman G, Lote K, Larson D, et al. Pretreatment factors predict overall survival for patients with low-grade glioma: a recursive partitioning analysis[J]. Int J Radiat Oncol Biol Phys, 1999, 45(4): 923-929.
-
3Nelson DF, Curran WJ, Scott C, et al. Hyperfractionated radi- ation therapy and bis-chlorethyl nitrosourea in the treatment of malignant glioma possible advantage observed at 72. 0 Gy in 1.2 Gy BID fractions: report of the Radiation Therapy On- tology Group Protocol 8302[J]. Int J Radiat Oncol Biol Phys, 1993,25(2) : 193-207.
-
4Youland RS, Brown PD, Giannini C, et al. Adult low-grade glioma: 19-year experience at a single institution[J]. Am J Clin Oncol, 2013, 36(6) :612-619.
-
5McGirt MJ,Chaichana KL,Gathinji M,et al. Independent association of extent of resection with survival in patients with malignant brain astrocytoma[J]. J Neurosurg, 2009,110 ( 1 ) :156-162.
-
6Tamura K, Aoyagi M, Wakimoto H, et al. Accumulation of CD133-positive glioma cells after high dose irradiation by gamma knife surgery plus external beam radiation[J]. J Neurosurg, 2010, 113(12): 310-318.
-
7Chibbaro S, Benvenuti L, Capfio A, et al. Temozolomide as first-line agent in treating high-grade gliomas: phase study [J]. Neurooneol ,2004, 67 (1/2): 77-81.
-
8Muragaki Y, Akimoto J, Maruyama T, et al. Phase II clinical study on intraoperative photodynamic therapy with talaporfin sodi- um and semiconductor laser in patients with malignant brain tumors [J~. J Neurosurg,2013,119(4) :845-852.
-
9Thomas AA, Brennan CW, DeAngelis LM, et al, Emerging thera- pies for glioblastoma [ J~. JAMA Neurol, 2014 , 71 ( 11 ) : 1437-1444.
-
10Bae SH, Park MJ, Lee MM, et al. Toxicity profile of temozolo- mide in the treatment of 300 malignant glioma patients in Korea [J]. J Korean Med Sei,2014,29(7) :980-984.
-
1范存刚,张庆俊.解读ESMO《高级别胶质瘤的诊断、治疗与随访指南》[J].国际神经病学神经外科学杂志,2012,39(6):566-569. 被引量:4
-
2马恒,赵兴圣,周茂义.肝癌微创治疗[J].中国中西医结合影像学杂志,2006,4(4):286-288. 被引量:1
-
3孙志强,陈信坚,金德勤,曾晓华,李国雄.多形性胶质母细胞瘤的影像与病理分析[J].放射学实践,2006,21(7):653-656. 被引量:15
-
4李文斌,康勋,张红梅,陈建新,Wen Patrick Y,江涛.高级别胶质瘤的治疗反应评价标准[J].中华神经外科杂志,2017,33(3):304-307. 被引量:11
-
5陈一平,朱建英,钟丽琴,潘锋.胶质母细胞瘤的CT、MRI表现与组织病理学的对照研究[J].现代实用医学,2011,23(8):849-851. 被引量:3
-
6张建华,漆剑频,黄文华,张进华,宋金梅,肖明,吴进.脑胶质瘤CT灌注成像与VEGF表达的对照研究[J].中国医学影像技术,2007,23(7):982-985. 被引量:6
-
7余光艳.1例疑是颅内感染的放射性脑坏死的分析[J].现代护理,2002,8(1):72-73.
-
8何华钰,王裕,马文斌.肿瘤治疗电场的研究进展[J].中华神经外科杂志,2017,33(3):308-310. 被引量:1
-
9郭栋,段海燕,汪滋民,何伟华.肩袖损伤脂肪浸润研究进展[J].国际骨科学杂志,2012,33(6):366-367. 被引量:6
-
10张家文,冯晓源,刘斌,余永强,刘含秋,孙军.64层CT灌注成像血管表面通透性测定对胶质瘤分级的价值[J].中国医学计算机成像杂志,2008,14(1):1-5. 被引量:10