摘要
目的探讨精子形态学变化及处理后前向运动精子总数（PTMS）对以男性因素为主的宫腔内人工授精（IUI）妊娠结局的影响。方法回顾性分析163例共266个男性因素为适应证的IUI周期,依照注入活动精子数分比较各组妊娠率,同时按Krüger＇s精子形态学严格标准法比较精子正常形态率对IUI妊娠率的影响。结果 266个周期中,临床妊娠39周期,周期妊娠率为14.66%,PTMS〈10×106（A组）、10×106≤PTMS〈20×106（B组）、PTMS≥20×106（C组）这三组发热妊娠率分别为8.57%、12.87%和21.05%,其中A组和C组比较差异具有统计学意义（P〈0.05）,而精子正常形态〈2%（Ⅰ组）、2%~4.5%（Ⅱ组）、5%~14.5%（Ⅲ组）、≥15%（Ⅳ组）这四组的妊娠率分别为3.03%、15.23%、15.11%和20.83%,第Ⅰ组和第Ⅳ组比较具有统计学意义（P〈0.05）。结论在男性因素为主的IUI周期中,精子正常形态率〈2%及精液处理后PTMS〈10×106时周期临床妊娠率明显下降。
Objective To assess the effect of morphological changes of sperm and processed total motile sperm（PTMS） count on the outcome of intrauterine insemination（IUI）.Methods A retrospective study was performed on 163 couples who underwent 266 IUI cycles.The pregnancy rates were compared according to the number of PTMS and the percentage of morphologically normal spermatozoa.Results A total of 39 clinical pregnancies were obtained in 266 treated cycles,with a pregnancy rate of 14.66%.The pregnancy rates were 8.57%,12.87% and 21.05% for groups with PTMS10×106（group A）,10×106 ≤PTMS20×106（group B） and PTMS≥20×106（group C）,respectively,with statistically significant difference betwwen group A and group C（P0.05）.The pregnancy rates were 3.03%,15.23%,15.11% and 20.83% for groups with the percentage of normal sperm 2%（groupⅠ）,2%~4.5%（groupⅡ）,5%~14.5%（group Ⅲ） and ≥15%（group Ⅳ）,with statistically significant difference between groupⅠ and group Ⅳ（P0.05）.Conclusion The clinical pregnancy rate declined distinctively when PTMS10×106,and sperm morphology was a significant factor that affects the success of IUI with male factor infertility.
出处
《海南医学》
CAS
2012年第8期1-3,共3页
Hainan Medical Journal
关键词
宫腔内人工授精
精子形态
前向运动精子总数
Intrauterine insemination
Sperm morphology
Processed total motile sperm count
