摘要
目的:观察应用大剂量氨溴索对早产儿呼吸窘迫综合征(NRDS)的防治效果。方法:随机将85例早产儿分为治疗组41例及对照组44例,在相同综合治疗基础上,治疗组加用氨溴索30 mg/(kg.d),连用5 d,观察患儿的生命体征及转归,总结NRDS发生率及使用呼吸机的情况,并对相关指标进行统计学分析。结果:治疗组中13例(31.71%)应用了新型鼻塞式持续气道正压通气(NCPAP),6例(14.63%)出现NRDS,上机率12.19%;对照组23例(52.27%)使用了NCPAP,15例(34.09%)发生NRDS,上机率29.55%。两组患儿上机后6 h、48 h的血气分析比较,PaO2、pH差异无统计学意义(P>0.05),PaCO2、PaO2/FiO2、RI及通气时间、住院天数比较差异均有统计学意义(P<0.05)。两组患儿除肺部感染差异有统计学意义外(P<0.05),其余并发症差异无统计学意义。结论:应用大剂量氨溴索有助于减少NRDS的发生,降低上机率,防治轻度NRDS。
Objective：To evaluate the effect of large dosage ambroxol in the prevention and treatment of neonatal respiratory distress syndrome（NRDS）.Methods：Randomly 85 newborns were divided into treatment group（41 cases） and control group（44 cases）.Besides the routine treatment,the treatment group were given ambroxol 30 mg/（kg·d） for 5 days additionally,and the control group was not given the intervention.The incidence of NRDS and mechanical ventilation（MV）were observed,and other indicators were statistically analyzed.Results：In the treatment group,13 cases used new nasal continuous positive airway pressure-type（NCPAP）,6 cases were diagnosed as NRDS,and 5 infants needed MV.The incidence was respectively 31.71%,14.63%,12.19%.In the control group,NCPAP was applied to 23 infants,15 infants were diagnosed as NRDS,13 cases needed MV.The morbidity was separately 52.27%,34.09%,29.55%.PaCO2,PaO2/FiO2 and RI were significantly different between the two groups after 6 h and 48 h MV（P0.01）,but PaO2 and pH had no difference（P0.05）.The time of ventilation and hospitalization had obvious change（P0.05）,and the rate of pulmonary infection in the treatment group was less than that in the control group（P0.01）.Conclusions：Large dose of ambroxol can significantly reduce the morbidity of NRDS and the rate of MV.It can effectively prevent and treat NRDS.
出处
《儿科药学杂志》
CAS
2012年第4期21-23,共3页
Journal of Pediatric Pharmacy
关键词
早产儿
呼吸窘迫综合征
氨溴索
鼻塞式持续气道正压通气
Premature infant
Respiratory distress syndrome
Ambroxol
Nasal continuous positive airway pressure
