摘要
目的探讨中国人群中HLA-DQAl基因拷贝数多态与胃癌发病风险的关系。方法采用定量聚合酶链反应方法，检测343例胃癌患者和330例正常对照者的HLA-DQAl基因拷贝数多态的基因型。采用Logistic回归模型分析各基因型患者胃癌的发病风险，以及基因一环境交互作用对胃癌发病风险的影响。结果携带HLA-DQAl基因2拷贝基因型的患者，胃癌发病风险显著升高（OR：1．87，95％CI为1．15～3．06，P=0．012）。HLA．DQAl基因拷贝数多态与幽门螺杆菌（Hp）感染存在基因一环境交互作用，携带HLA．DQAl基因2拷贝基因型且感染坳的患者，胃癌发病风险显著增高（OR=3．89，95％CI为1．75～8．57，P=0．001）。结论HIJA-DQAl基因拷贝数多态是胃癌的遗传易感因素，与坳感染存在交互作用。
Objective To explore the association between HLA-DQA1 gene copy number polymorphisms and gastric cancer risk in Chinese population, and the interaction of those genes and environmental factors. Methods The genotype of HLA-DQA1 gene copy number polymorphisms was determined in 343 patients with gastric cancer and 330 controls by quantitative polyrnerase chain reaction. Logistic regression model was used to evaluate the impact of this polymorphism on the risk of developing gastric cancer and the gene-environment interaction. Results Compared with 0 copy of HLA-DQA1 gene carriers, the 2 copies of HLA-DQA1 gene carriers had a significantly increased risk of gastric cancer （ OR = 1.87, 95% CI = 1.15-3.06, P = 0.012）. Gene-environment interaction of HLA-DQA1 gene copy number polymorphisms and Helicobacter pylori infection significantly increased the risk of gastric cancer in a multiplicative manner, with an OR of 3.89 （ 95% CI = 1.75-8.57, P = 0. 001 ）. Conclusions HLA- DQA1 gene copy number polymorphism is associated with gastric cancer susceptibility, and there is a multiplicative gene-environment interaction between this polymorphism and Hp infection in the development of gastric cancer.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2012年第4期269-271,共3页
Chinese Journal of Oncology
