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中国南方汉族人群ApoC3基因启动子区-482C→T多态性与糖尿病肾病的相关性研究. 被引量:1

The study of the association between ApoC3 gene promoter region-482C→T polymorphism and diabetic nephropathy
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摘要 目的探讨载脂蛋白C3(ApoC3)基因启动子区-482C→T多态性与中国人DN的相关性。方法运用聚合酶链反应-限制性片段长度多态性技术(PCR-RFLP),在中国人群中对179例T2DM患者和60名正常对照者(NC)的ApoC3基因启动子区-482C→T的多态性进行检测,并比较各组间基因型频率和等位基因频率以及相关临床资料。结果 DN组(DN1+DN2)的T/T基因型频率及T等位基因频率高于DN0组(P<0.01),但DN2与ND1组间T/T基因型频率及T等位基因频率差异无统计学意义(P>0.05)。T2DM组中,T/T基因型组患者的血TG水平及24hUAlb均高于C/T和C/C基因型组者(P<0.01)。Logistic回归分析表明:ApoC3基因启动子区-482C→T多态性和DM病程与DN显著相关,-482T/T基因型是DN发生的危险因素;DN患者中,DM病程>5年是DN2发生的危险因素。结论在中国南方汉族人群中,ApoC3基因启动子区-482T/T基因型可能是DN发生的危险因素;病程>5年可能是DN进展的危险因素。 Objective To investigate the association between ApoC3 gene promoter region insulin response element-482C→T polymorphism and diabetic nephropathy.Methods The polymorphism of ApoC3 gene promoter region-482C→T was detected by PCR-RFLP method in 179 unrelated Chinese with type 2 diabetes(DM group) and 60 normal controls(NC group).The genotype frequency,allele frequency and relative clinical data were compared between groups.Ressults The frequencies of T/T genotype and T allele were significantly higher in DN(DN1+DN2) group than in DN0 group(P〈0.01).However,there were no significant differences in genotype between DN1 and DN2 groups(P〉0.05).In DM(DN0+DN1+DN2) group,triglyceride(TG) and 24h urinary albuminuria(UAlb) were significantly higher in T/T genotype group than in C/T and C/C genotype groups(P〈0.01).Logistic regression analysis showed that ApoC3 gene promoter region-482C→T polymorphism and diabetic duration were risk factors for DN occurrence.Conclusion The ApoC3 promoter region-482T/T genotype may be a risk factor of DN occurrence.Diabetic duration 〉5 years may be a risk factor for the progress of diabetic nephropathy in Chinese.
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2012年第4期263-266,共4页 Chinese Journal of Diabetes
关键词 载脂蛋白C3基因 多态性 糖尿病肾病 ApoC3 gene Polymorphism Diabetic nephropathy
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  • 1郭晓蕙.脂毒性导致肾损伤的机制[J].国外医学(内分泌学分册),2005,25(3):161-163. 被引量:13
  • 2Talmud PJ,Hawe E,Martin S,et al.Relative contribution ofvariation within the APOC3/A4/A5gene cluster in determi-ning plasma triglycerides.Hum Mol Genet,2002,11:3039-3046.
  • 3Waterworth DM,Talmud PJ,Bujac SR,et al.Contribution ofapolipoproteinC3gene variants to the determination of triglyc-eride levels and interaction with smoking in middle-aged men.Arterioscle Thromb Vasc Biol,2000,20:2663-2669.
  • 4Miller M,Rhyne J,Chen H,et al.APOC3promoter polymor-phisms C-482Tand T-455Care associated with the metabolicsyndrome.Arch Med Res,2007,38:444-451.
  • 5Qi L,Liu S,Rifai N,et al.Associations of the apolipoproteinA1/C3/A4/A5gene cluster with triglyceride and HDL choles-terol levels in women with type 2diabetes.Atherosclerosis,2007,192:204-210.
  • 6Alborn WE,Prince MJ,Konrad RJ,et al.Relationship of apoli-poprotein A5and apolipoprotein C3levels to serum triglycer-ides in patients with type 2diabetes.Clin Chim Acta,2007,378:154-158.
  • 7Miller M,Rhyne J,Khatta M,et al.Prevalence of the ApoC3Promoter polymorphisms T-455Cand C-482Tin Asian-Indi-ans.Am J Cardiol,2001,87:220-221.
  • 8Baum L,Ng MC,So WY,et al.Effect of hepatic lipase-514C→T polymorphism and its interactions with apolipoprotein C3-482C→T and apolipoprotein E exon 4polymorphisms on therisk of nephropayhy in Chinese type 2diabetic patients.Diabe-tes Care,2005,28:1704-1709.
  • 9Guettier JM,Georgopoulos A,Tsai MY,et al.Polymor-phisms in the fatty acid-binding protein 2and apolipoprotein C-Ⅲgenes are associated with the metabolic syndrome and dys-lipidemia in the south Indian population.J Clin EndocrinolMetab,2005,90:1705-1711.
  • 10Waterworth DM,Ribalta J,Nicaud V,et al.ApoCⅢgenevariants modulate postprandial response to both glucose and fattolerant tests.Circulation,1999,99:1872-1877.

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