摘要
目的:观察中医药辨证论治早期干预无症状期HIV感染者的有效性和安全性。方法:采用随机、双盲、安慰剂平行对照临床研究方法,选择无症状期HIV感染者133例作为受试者,随机分为试验组和对照组,比例约2∶1。受试者入组后,根据中医辨证结果服用相应药物,试验组给予相应证型中药制剂,对照组给予相应证型中药制剂的模拟剂,每月辨证1次,每次根据辨证结果选用相应药物,试验周期18个月。观察安全性指标和疗效性指标。结果:中药组在降低发病率和升高CD4+计数方面优于安慰剂组,在降低病毒载量方面差异无统计学意义。结论:中医药辨证论治对133例无症状期HIV感染者早期干预疗效显著,为优化形成无症状期HIV感染者的中医药防治方案提供科学依据。
Objective：To make effectiveness and safety evaluation on TCM＇s intervention with asymptomatic HIV infected persons.Methods：This study applied a randomized,double-blind,and placebo-parallel control designed method to select 133 persons in the asymptomatic period of HIV infection as the subjects.The subjects were randomly divided into the test group and the control group at the ratio of about 2：1.According to the results of monthly differential diagnosis of TCM,the test group and the control group were given homologue Chinese drugs preparations and model Chinese drugs,and the effectiveness and safety indexes were recorded.The total study period was 18 months.Results：Chinese drugs preparations were superior to model Chinese drugs in reducing morbidity and increasing CD＋4 count,but there was no statistical significance in reducing viral load between these two groups.Conclusion：TCM＇s differential diagnosis and treatment of 133 asymptomatic HIV infected persons show an evident effect of early intervention,providing scientific basis to the optimization of the TCM prevention and treatment of asymptomatic HIV infected persons.
出处
《辽宁中医杂志》
CAS
2012年第4期667-669,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
国家"十一五"科技重大专项项目(2008ZX10005-002)
关键词
中医药
辨证论治
无症状HIV感染者
traditional Chinese medicine
syndrome differentiation and treatment
asymptomatic HIV infected person
