摘要
目的:探讨维持性血液透析(MHD)患者抑郁症及相关因素的关系。方法:对44例维持性血液透析患者进行Zung抑郁自评量表(SDS)评分。调查抑郁状态在该人群中的患病率;比较抑郁组和非抑郁组的一般情况、透析情况、躯体症状、各实验室指标;用肾脏病生活质量简表(KDQOL-SF)对该人群进行评分,调查抑郁状态对患者生活质量的影响。结果:SDS评分显示该组患者抑郁状态患病率58.8%。抑郁组和非抑郁组的年龄、工作状况、躯体症状、透析方式、内瘘手术次数、透析前血尿酸浓度比较,差异有显著性(P<0.05),家庭支持度高、经济状况好的MHD患者,抑郁症发病率低。抑郁组与非抑郁组生活质量分值差异有显著性,KDQOL-SF分值与SDS评分存在负相关(r=-0.871,P<0.05)。结论:MHD患者抑郁状态患病率明显高于正常人群。60岁以上、没有工作、无定期血液滤过(HF)或血液透析滤(HDF)、内瘘手术次数多、透析前血尿酸较高,家庭支持度低、经济状况差的患者抑郁状态患病率高。抑郁组生活质量明显低于非抑郁组。
Objective： To investigate the prevalence of depression in with end-stage renal disease（ESRD） undergoing maintenance hemodialysis and analyze the related factors of depression. Methods; 44 patients with ESRD undergoing he- modialysis were assessed by Zung Self-rating Depression Scale （SDS）. The social-family-economic background, dialysis status and bicchemistric indexes of these patients were analyzed. All patients were assessed by the Kidney Disease Quality of Life short from（KDQOL-SF） to investigate the effect of depression on quality of life. Results： 58. 8% of pa- tients had SDS score higher than 40, which means the prevalence rate of depression in these patients was 58. 8%. These were significant difference in age, employment status, dialysis method, operation times of internal fistula and concentra- tion of uric acid between the depression group and the non-depression group（P〈0. 05）. The KDQOL-SF score of the depression group was significantly lower than the non-depression group（P〈0. 05）, and there exist negative eorrlation between the KDQOL-SF score and the SDS score in there patients. Conclusion：The prevalence rate of depression in pa- tients with ESRD undergoing maintenance hemodialysis was significantly higher than in the general population. Patients who over 60 years old. Or have no job, or never take regular periodic hemofiltration or hemodiafiltration, or xpefience more times of fistula operation,or have higher concentration of uric acid may have higher prevalence rate of depression.
出处
《医学理论与实践》
2012年第8期882-884,894,共4页
The Journal of Medical Theory and Practice
