摘要
目的观察甲氨蝶呤联合米非司酮治疗未破裂型输卵管妊娠的临床效果。方法96例未破裂型输卵管妊娠患者随机分为两组，观察组48例采用甲氨蝶呤联合米非司酮治疗，对照组48例仅采用甲氨蝶呤治疗，观察两组的治疗效果及不良反应情况。结果观察组血β-HCG降至正常时间（9．6±2．1）d、住院时间（2251．6±78．9）d明显少于对照组[（15．2±3．4）d，（2337．8±72．7）d]，包块直径（1．14±0．46）cm缩小程度明显大于对照组（2．23±0．61）cm（P〈0．05）。观察组不良反应发生率为10．4％（5／48），对照组不良反应发生率为6．3％（3／48），差异无统计学意义（P〉0．05）。结论甲氨蝶呤联合米非司酮对未破裂型输卵管妊娠进行治疗，能够明显提高疗效，缩短治疗时间，不良反应少，值得临床推广应用。
Objective To observe the clinical effect of methotrexate combined with mifepristone in the treatment of unruptured ectopic pregnancy. Methods 96 cases of unruptured ectopic pregnancy patients were randomly classified into two groups,observation group with 48 cases was treated with methotrexate combined with mifepristone and control group with 48 cases was only treated with methotrexate. The treatment effect and adverse reaction between two groups were compared. Results The time of blood β-HCG recovery to normal and hospitalization time in observation group were significantly shorter than those in control group （P 〈 0.05 ）, and mass diameter was significantly smaller than that in control group （ P 〈 0.05 ）. The adverse reaction incidence in observation group was 10.4% （ 5/48 ） while 6.3 % （3/48） in control group. Conclusion Methotrexate combined with mifepristone in the treatment of unruptured ectopic pregnancy could enhance clinical effect, shorten treatment time, decrease adverse reaction, which could be applied in clinic.
出处
《中国基层医药》
CAS
2012年第7期981-982,共2页
Chinese Journal of Primary Medicine and Pharmacy
