摘要
目的 观察高温顺铂肢体区域性隔离灌注的局部和全身不良反应。方法 12只青紫兰兔随机分成两组 ,在相同灌注条件下 ,一组用DDP(2mg/kg体重 )灌注 ,另一组用生理盐水灌注。灌注前及灌注后第 3天测定相关血生化 ,电解质及白细胞计数。观察肢体感染、水肿、运动等功能。根据Wiberdinks分级评价局部不良反应等级。另 1只动物按 4mg/kg体重DDP灌注 ,观察上述指标。 结果 在灌注及随访期间无动物死亡。两组实验动物灌注前后AST、AKP、Cr,电解质无明显差异。实验组LDH ,CK灌注后有显著升高。ALT、Urea、白细胞在DDP组与灌注前有差异 ,前者高于后者。除轻度胃肠道反应外 ,无严重肝肾功能受损 ,骨髓抑制等不良反应。局部肢体毒性分级 ,DDP组明显高于无药组。按 4mg/kg体重灌注的动物出现明显的全身及局部不良反应。 结论 用高温 2mg/kg顺铂肢体区域性灌注无全身严重并发症 ,局部不良反应也较轻 。
Objective To gain some insight into acute local and systemic toxicity reation after hyperthermic isolated perfusion of DDP. Methods Twelve rabbits were randomly divided into two groups. DDP group consisted of 2 mg/kg body weight as the average perfusion dose and the control group perfused with normal saline solutions only one other rabbit was perfused with DDP of 4mg/kg body weight. Blood specimens were collected to test ALT, AST, AKP, Urea, Cr LDH, CK, WBC, K +, Na +, CL - before and two days after perfusion. Wound infection, edema, motility function were observed within one month after perfusion. Acute regional toxicity was graded according to Wieberdink's grading system. Results No rabbit expired within one month after perfusion. AST, AKP, Cr and electrolytes did not differ significantly before and after perfusion in both DDP and control groups ( P >0.05). Significant differences among the three groups existed in LDH, CK. Significant differences were shown between the DDP group and the pre perfusate group, the DDP group and no drug group. There were also significant differences in Urea, WBC between DDP and pre perfusate groups. The grade of regional toxicity reaction in DDP group was higher than that in control group ( P <0.05). Acute regional and systemic toxicity reaction were observed in the rabbits perfused with DDP of 4mg/kg body weight. Conclusions Hyperthermic perfusion of DDP in a dosage of 2mg/kg body weight in isolated rabbit limbs is a safe therapy with lesser on mild acute regional toxic reaction and no serious systemic toxic reaction.
出处
《介入放射学杂志》
CSCD
2000年第2期102-104,共3页
Journal of Interventional Radiology
