摘要
目的分析三维适形放疗(3-DCRT)联合GP方案化疗治疗局部晚期胰腺癌的临床疗效。方法 40例局部晚期胰腺癌随机分为2组,治疗组22例给予3-DCRT联合GP方案化疗,对照组18例仅给予3-DCRT,治疗结束后评价临床疗效和毒副反应。结果治疗组和对照组中位生存期分别为15个月和7个月,差异有统计学意义(P<0.05)。治疗组6个月和12个月生存率分别为86.4%、68.2%,高于对照组的50.0%、33.3%,差异有统计学意义(P均<0.05)。主要毒副反应为胃肠道反应和骨髓抑制,但均较轻。结论 3-DCRT联合GP方案化疗治疗局部晚期胰腺癌安全有效。
Objective To observe the clinical efficacy of three-dimensional conformal radiotherapy （3-DCRT） combined with GP regimen chemotherapy in the treatment of patients with locally advanced pancreatic cancer. Meth. otis The 40 patients with locally advanced pancreatic cancer were randomly divided into two groups ： the 22 patients in the therapy group received 3-DCRT combined with GP regimen chemotherapy ,the 18 patients in the control group received 3-DCRT alone. The clinical efficacy and the toxicities were observed after the treatment. Results The median survival time was 15 months in the therapy group, and was 7 months in the control group （P 〈 0.05 ）. The 6 and 12 month survival rates were respectively 86.4% and 68.2% in the therapy group, and were respectively 50.0% and 33.3% in the control group （P 〈 0.05 ）. The main toxicities were gastrointestinal reaction and marrow suppression. Conclusion 3-DCRT combined with GP regimen chemotherapy is effect and safe for the patients with locally advanced pancreatic cancer.
出处
《肿瘤基础与临床》
2012年第2期133-135,共3页
journal of basic and clinical oncology
关键词
胰腺癌
三维适形放疗
化疗
pancreatic.cancer
three-dimensional conformal radiotherapy
chemotherapy
