摘要
目的探讨全脑放疗在脑转移癌姑息性治疗中的疗效。方法 98例脑转移癌姑息性全脑放疗患者根据放疗分割方式的不同分为3组,均选用6 MV-X线全脑照射,每天1次,每周5次。A组45例:DT 40Gy/20次/4周;B组20例:DT 30 Gy/15次/3周;C组23例:DT 30 Gy/10次/2周。分析不同分割方式全脑放疗后患者的生存情况。结果 A组、B组、C组的总有效率分别为97.8%、95.0%、95.7%(P>0.05)。A组、B组、C组的中位生存期分别为11.5、11.0、10.8个月;1 a生存率分别为40.0%、30.0%、34.8%(P>0.05);2 a生存率分别为11.1%、10.0%、8.7%(P>0.05)。3组患者的KPS评分比较差异无统计学意义(P>0.05)。结论全脑放疗对脑转移癌患者疗效较好,毒副反应轻,其中DT 30 Gy/10次/2周的分割方式较其他2种方式具有节约医用资源的优势。
Objective To study the effect of whole brain radiotherapy in the treatment of intracranial metastases. Methods According to the time-dosage fractionation regimen, 98 patients were divided into three groups, and re- ceived 6 MV-X ray radiotherapy, 1 time/d ,5 times/week. Forty five patients in the A group： DT 40 Gy/20 times/4 weeks; 20 patients in the B group： DT 30 Gy/15 times/3 weeks; 23 patients in the C group： DT 30 Gy/10 times/ 2 weeks. Results The response rates were 97.8%, 95.0% and 95.7% in the A group, the B group and the C group （ P 〉 O. 05 ）. The median survival time of the A group, the B group, the C group were 11.5,11.0 and 10.8 months; the 1-year survival rates were 401 0% , 30.0% and 34.8% （P 〉 0.05 ） ; the 2-year survival rates were 11.1% ,10.0% and 8.7% （P 〉0.05）. There was no statistic difference in the KPS scores among the three groups （ P 〉 0.05 ）. Conclusion The whole brain radiotherapy is effective for the patients with intracranial metastases, the regimen of the C group （DT 30 Gy/10 times/2 weeks） can save medical resources.
出处
《肿瘤基础与临床》
2012年第2期138-140,共3页
journal of basic and clinical oncology
关键词
脑转移癌
全脑放疗
分割方式
预后
intracranial metastases
whole brain radiotherapy
time-dosage fractionation regimen
prognosis
