抗VEGF药物在眼科疾病中的应用及机制研究进展被引量：4

Research progress on the clinical application and basic Mechanism of anti-VEGF drug

下载PDF

导出

摘要目前研究表明,许多眼科疾病的发生、发展的病理基础为眼部异常血管的增生,其与VEGF的调节与表达密切相关。随着抗VEGF药物的研发及应用,抗VEGF药物在眼部疾病尤其是眼部血管增生性疾病中的治疗中起着极为重要作用。本为对目前抗VEGF的3种药物(Avastin、Lucentis、Macugen)在眼科疾病中的应用概况及相关机制做一综述。 Angiogenesis is the main pathologic characters in many ocular diseases.The regulation and expression of Vascular endothelial growth factor（VEGF） is closely related to many ocular vascular disease such as advanced age-related macular degeneration,diabetic retinopathy,neovascular glaucoma.With the development and application of anti-VEGF drug,it plays an extremely important role on ocular vascular eye diseases,especially ocular vascular disease.The review focuses on the clinical application and basic Mechanism of the anti-VEGF drug,including Avastin、Lucentis、Macugen.

作者金晓曹丽娜

机构地区嘉兴朝聚眼科医院

出处《中外医疗》 2012年第8期181-182,共2页 China & Foreign Medical Treatment

关键词 VEGF AVASTIN LUCENTIS MACUGEN 血管增生性眼病 VEGF Avastin Lucentis Macugen ocular vascular disease

分类号 R9 [医药卫生—药学]

引文网络
相关文献

参考文献2

1于同利,毕宏生.Avastin在眼科应用的研究进展[J].国际眼科杂志,2008,8(4):810-812. 被引量：23
2宋徽,任兵,高晓唯.Bevacizumab(Avastin)对眼科疾病的治疗作用[J].国际眼科杂志,2008,8(6):1230-1232. 被引量：16

二级参考文献23

1周洪伟,吴强.血管内皮生长因子及其受体与眼底新生血管[J].国际眼科杂志,2007,7(3):791-795. 被引量：17
2李贞,倪卫杰.视网膜新生血管生物药物治疗研究进展[J].国际眼科杂志,2007,7(4):1119-1123. 被引量：17
3Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil and leucovorin for metastatic colorectalcancer. N Engl J Med 2004 ;350(23 ) :2335-2342
4La Cour M. Intravitreal VEGF-inhibitors: is Avastin a generic substitute for Lueentis?Aeta Ophthalrnol Scand 2007 ;85:2-4
5Luthra S, Narayanan R, Marques LE, et al. Evaluation of in vitro effects of bevaeizumab(Avastin) on retinal pigment epithelial, neuroscnsory retinal, and mierovaseular endothelial cells. Retina 2006 ;26:512-518
6Erdurmus M ,Totan Y. Subconjunctival avastin for corneal neovascularization. Graefe Arch Clin Exp Ophthalmol 2007 ;26(5 ) : 1125-1129
7Iliev ME, Domig D, Wolf-Schnurrbursch U, et al. Intravitreal be-vacizumab(Avastin) in the treatment of neovasctdar glaucoma.Am J Ophthalmol 2006 ; 142 : 1054-1056
8Davidorf FH, Mouser JG, Derick RJ. Rapid improvement of rubeosis iridis from a single bevacizumab(avastin) injection. Retina 2006 ;26( 3 ) : 354-356
9Iturralde D, Spaide RF, Meyerle CB, et al. Intravitreal bevacizumab (Avastin) treatment of macular edema in central retinal vein occlusion.a short-term study. Retina 2006 ;26 ( 3 ) :279-284
10Rosenfeld PJ, Andrew A, Moshfeghi AA, et al. Optical coherence tomography findings after an intravitreal injection of bevacizumab (avastin) for neovasoular age-related macular degeneration. Ophthalmic Surg Lasers Imaging 2005 ;36:331-335