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肺癌靶向治疗研究进展 被引量：3

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摘要 目的对国内外肺癌靶向治疗相关研究进行总结。方法以"肺癌"及"靶向治疗"为关键词,在CNKI及PUBMDE期刊中检索近10年来的中文及英文文献资料。以表皮生长因子受体酪氨酸激酶抑制剂、以肿瘤血管生成为靶点的治疗以及多靶点治疗在肺癌中的作用为标准,针对24篇文章进行分析。结果在表皮生长因子受体酪氨酸激酶抑制剂领域的研究相对成熟,特别是吉非替尼,相关临床治疗实验表明,对吉非替尼二线治疗效果方面发挥决定性影响的可能是EGFR突变;在以肿瘤血管生成为靶点的治疗上,对于复发NSCLC患者而言,贝伐单抗与化疗联合使用与化疗单独使用相比,前者对于PFSD的提升效果更为明显;在晚期NSCLC治疗中,血管内皮抑素Ⅲ期实验表明,血管内皮抑素与NP联合使用域NP单独使用相比,前者有效率明显高于后者。结论肺癌靶向治疗相关研究进展较快,具有极为广阔的应用前景,为肺癌治疗开辟新思路。
作者 董耀众
机构地区 烟台毓璜顶医院
出处 《中外医疗》 2012年第9期189-189,共1页 China & Foreign Medical Treatment
关键词 肺癌 靶向治疗 研究进展
分类号 R734.2 [医药卫生—肿瘤]
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共引文献17

同被引文献43

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中外医疗
2012年 第9期

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