期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

一种苯并噁嗪衍生物的合成与NMR结构分析

Synthesis and NMR Study of a Novel Benzoxazine
下载PDF
导出
摘要 以丹皮酚为原料,通过三步反应成功合成一种苯并噁嗪类化合物,该合成方法简便,产率高,方便提纯.另外,利用1H NMR、13C NMR结合2D NMR(HSQC和HMBC)对该化合物的结构进行了全解析. A novel benzoxazine was synthesized via three-step reaction as the material of paeonol,this simple synthetic method is high yield and the product was obtained easily by recrystallizing. Furthermore,the structure of this benzoxazine was studied by 1H NMR, 13C NMR and 2D NMR （HSQC and HMBC）.
作者 陈彤 黄梦林 张宝军 袁金伟 陈晓岚
机构地区 河南省科学院高新技术研究中心 郑州大学化学系 河南工业大学化学化工学院
出处 《河南科学》 2012年第4期420-423,共4页 Henan Science
基金 国家自然科学基金(21072178)
关键词 丹皮酚 苯并噁嗪 NMR 结构分析 paeonol： benzoxazine： NMR： structural analysis
分类号 O624.6 [理学—有机化学]
  • 相关文献

参考文献10

  • 1Mordarski M,Chylinska J B.Antitumor properties of 1,3-oxazine derivatives.Derivatives of dihydro-1,3-oxazine condensedwith an aromatic ring in position 5,6[J].Arch Immunol Ther Exp,1971,19(4):533-545.
  • 2Chylinska J B,Urbanski T,Mordarski M.Dihydro-1,3-oxazine derivatives and their antitumor activity[J].J Med Chem,1963,6(5):484-487.
  • 3Kuehne M E,Konopka E A.Dihydro-1,3-oxazines as antitumor agents[J].J Med Pharma Chem,1962,5(2):257-280.
  • 4Hays S J,Caprathe B W,Gilmore J L,et al.2-Amino-4H-3,1-benzoxazin-4-ones as inhibitors of clr serine protease[J].J MedChem,1998,41(7):1060-1067.
  • 5Zhang P W,Terefenko E A,Fensome A,et al.6-Aryl-1,4-dihydro-benzo[d][1,3]oxazin-2-ones:a novel class of potent,selective,and orally active nonsteroidal progesterone receptor antagonists[J].J Med Chem,2002,45(20):4379-4382.
  • 6Zhang P W,Terefenko E A,Fensome A,et al.Potent nonsteroidal progesterone receptor agonists:synthesis and SAR study of 6-arylbenzoxazines[J].Bioorg Med Chem Lett,2002,12(5):787-790.
  • 7Kondo K,Seki M,Kuroda T,et al.2-Substituted 2,3-dihydro-4H-1,3-benzoxazin-4-ones:a novel auxiliary for stereoselectivesynthesis of 1-beta-methylcarbapenems[J].J Org Chem,1995,60(5):1096-1097.
  • 8Kondo K,Seki M,Kuroda T,et al.2-Substituted 2,3-Dihydro-4H-1,3-benzoxazin-4-ones:novel auxiliaries for stereoselectivesynthesis of 1-β-methylcarbapenems[J].J Org Chem,1997,62(9):2877-2884.
  • 9Chou T C.Anti-inflammatory and analgesic effects of paeonol in carrageenan-evoked thermal hyperalgesia[J].British J Pharm,2003,139(6):1146-1152.
  • 10计春燕,谭诗云,刘长青.丹皮酚对人大肠癌细胞凋亡和细胞周期以及患者预后的影响[J].中国临床康复,2005,9(6):122-124. 被引量：17

二级参考文献11

  • 1Litvak DA, Bilcbik A J, Cabot MC. Modulators of ceramide metabolism sensitize colorectal cancer cells to chemotherapy: a novel treatment strategy. J Gastrointest Surg 2003; 7 (1): 140 - 8; discussion 148.
  • 2Keepers YP, Pizao PE, Peters GJ, et al. Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing. Eur J Cancer 1991; 27:897 - 900.
  • 3Chung-Faye GA, Kerr DJ, Young LS, et al. Gene therapy strategies for colon cancer. Mol Med Today 2000; 6 (2): 82 - 7.
  • 4Todryk S, Melcher A, Bottley G, et al. Cell death associated with genetic prodrug activation therapy of colorectal cancer. Cancer Letters 2001; 174:25 - 33.
  • 5Chang HL, Hung CF, Yeh CC, et al. Paeonol promoted 2-aminofluorence and p-amiobenzoic acid acetylations by mononuclear leucocytes from Sprague-Dawley rats. Cytobios 2000; 103(404): 149 -58.
  • 6Chung JG. Paeonol promotion of DNA adduct formation and arylamines N-acetyltransferase activity in human colon tumour cells. Food Chem Toxicol 1999; 37(4): 327 -34.
  • 7Tebbutt NC, Cattell E, Midgleym R, et al. Systemic treatment of colorectal cancer. Eur J Cancer 2002;38:1000 - 15.
  • 8Koyama F, Sawada H, Fujii H, et al. Adenoviral-mediated transfer of Escherichia coli uracil phosphoribosyltransferase (UPRT) gene to modulate the sensitivity of the human colon cancer cells to 5-fluorouracil. Eur J Cancer 2000; 36:2403 - 10.
  • 9丘少鹏,王道虎,刘卓炜,李俊彪,梅骅.丹皮酚磺酸钠在动物肾缺血再灌注损伤中的作用[J].中华肾脏病杂志,2001,17(3):185-187. 被引量：49
  • 10孙国平,沈玉先,张玲玲,周爱武,魏伟,徐叔云.丹皮酚对HepA荷瘤小鼠免疫调节和抑瘤作用研究[J].中国药理学通报,2003,19(2):160-162. 被引量：65

共引文献16

河南科学
2012年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部