摘要
目的观察奥曲肽联合清蛋白、呋塞米治疗肝肾综合征(HRS)的临床疗效。方法将42例HRS患者随机分为两组:治疗组19例,给予奥曲肽、清蛋白、呋塞米先后用药及其他护肝等综合治疗;对照组23例,常规给予清蛋白和呋塞米及其他护肝等综合治疗。比较两组患者治疗后的疗效及治疗前后血肌酐、尿素氮、24 h尿量的变化。结果治疗后治疗组患者血肌酐、尿素氮水平较对照组显著降低,24 h尿量较对照组显著增加,差异有统计学意义(P<0.05)。治疗组治疗后治愈5例,好转7例,无效7例;对照组治愈3例,好转5例,无效15例,两组患者疗效间差异有统计学意义(P<0.05)。结论奥曲肽联合清蛋白、呋塞米是治疗HRS的有效方法,可降低血肌酐、尿素氮水平,增加尿量。
Objective To observe the clinical effect of octreotide combined with albumin and furosemide treatment of hepatorenal syndrome patients. Methods 42 patients with hepatorenal syndrome were randomly divided into two groups. The 19 patients in treatment group were treated with octreotide combined with albumin and furosemide therapy and other comprehensive treatment of liver protection ; 23 patients in control group were treated with normal albumin and furosemide, and other comprehen- sive treatment of liver protection. The clinical effect was compared between the two groups and creatinine, blood urea nitrogen and 24 - hour urine volume changes were observed before and after treatment. Results The levels of creatinine and blood urea nitro- gen in treatment group were significantly lower than those in control group, while the 24 - hour urine volume was significandy in- creased in treatment group than in control group （ P 〈 0.05 ） . After treatment, 5 cases were cured, 7 cases were improved and 7 cases were ineffective in treatment group, while 3 cases were cured, 5 cases were improved and 15 cases were ineffective in con- trol group. The difference of clinical effect between the two groups was statistically significant （ P 〈 0.05 ） . Conclusion Oct- reotide combined with albumin and furosemide is an effective method for the treatment of hepatorenal syndrome, which can be im- proved in terms of reducing the levels of creatinine and blood urea nitrogen and increasing 24 - hour urine volume.
出处
《中国全科医学》
CAS
CSCD
北大核心
2012年第12期1350-1352,共3页
Chinese General Practice
关键词
肝肾综合征
奥曲肽
清蛋白
呋塞米
治疗结果
Hepatorenal syndrome
Octreotide
Albumin
Furosemide
Treatment outcome
