摘要
由廉价易得的1,2-环己二胺作为起始原料,通过简单的合成步骤制备了一种新型的四齿膦配体1,并将该配体应用于钯催化的Suzuki交叉偶联反应中.在仅为0.1 mol%的催化剂用量下,成功地实现了多种氯/溴代芳烃、氯/溴代杂环芳烃以及溴代烷烃底物与苯硼酸的交叉偶联反应,产率最高可达99%.
A new tetraphosphine,N,N,N＇,N＇-tetra（diphenylphosphinomethyl）-cyclohexane-1,2-diamine（1） has been designed and synthesized from the commercially available cyclohexane-1,2-diamine as starting material.This tetraphosphine in combination with [Pd（η3-C3H5）Cl]2 is a very efficient catalyst for Suzuki cross-coupling reaction.Various aryl-and heteroaryl-chlorides as well as aryl-,heteroaryl-,and alkyl-bromides could be successfully transformed to the desired products in up to 99% yield with 0.1 mol% catalyst loading.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2012年第4期790-793,共4页
Chinese Journal of Organic Chemistry
关键词
催化
钯
四膦配体
Suzuki交叉偶联
苯硼酸
catalysis
palladium
tetraphosphine
Suzuki cross-coupling
phenylboronic acid
