摘要
本文检测24例狼疮肾炎(LN)患者、7例无临床肾损害表现的SLE患者及11例正常人尿血栓素B_2(TXB_2)、6-酮-前列腺素F_1α(6-Keto-PGF_1α)排泄水平。结果示LN病人尿TXB_2/6-Keto-PGF_1α(T/K)值较无临床肾损害SLE患者及正常人均增高,差异显著,且T/K值与肾有效血浆流量(REPF)呈显著性负相关;与24小时尿蛋白呈显著性正相关。尿T/K值可作为临床上判断LN患者病情和估计预后的指标之一。
Urinary excretion of thromboxane B_2 (TXB_2) and 6-keto PGF_1a weremeasured in 24 patients with lupus nephritis (LN),7 SLE patients withoutclinical renal lesions and 11 healthy controls.The results showed that:LNpatients had significantly higher ratio of urinary TXB_2/6-keto PGF_1a(T/K)than that in SLE patients without clinical renal lesions and healthy con-trots.The ratio was a significant negative correlation to renal efficient plas-ma flow (REPF),and a significant positive correlation to urinary protein in24 hours.The ratio of urinary T/K may serve as an indicator for assessingthe activity and prognosis in LN patients.
出处
《中国皮肤性病学杂志》
CAS
北大核心
1990年第3期141-143,190-193,共3页
The Chinese Journal of Dermatovenereology
