摘要
目的探讨西瓜霜喷剂对口腔溃疡大鼠的改善作用及相关机制。方法通过石碳酸烧灼法制备口腔溃疡SD大鼠40只,随机分为西瓜霜喷剂组和生理盐水组,处理1周后观察口腔溃疡大鼠的症状改善情况,并检测血浆炎性因子水平(IL-2、IL-4、IL-6、IL-8)和T细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)变化情况。结果①西瓜霜喷剂组的治疗总有效率和指标改善情况均优于生理盐水组;②西瓜霜喷剂可改善口腔溃疡大鼠的血浆IL-2降低水平和IL-4、IL-6、IL-8升高的水平,并恢复口腔溃疡大鼠的T细胞CD3+、CD4+、CD4+/CD8+水平升高、CD8+水平降低。结论西瓜霜喷剂可改善口腔溃疡大鼠症状,机制可能是通过降低机体的炎症反应水平和纠正免疫功能紊乱来加快黏膜愈合。
Objective To explore the improvement effects of watermelon frost spray on rats with oral ulcers and related mechanisms. Methods Forty SD rats with oral ulcers were prepared by phenol burning and randomly divided into watermel- on frost spray group and saline group. The improvement of symptoms and plasma levels of inflammatory cytokines and changes in T cell subsets were investigated after treatment one week. Results The overall efficiency and improvement situ- ation of indicators in watermelon frost spray group were better than the saline group;Watermelon frost spray can improve the decreased plasma IL-2 and elevated IL-4, IL-6, IL-8 level as well as increased T-cell CD3＋, CD4＋, CD4＋/CD8＋ levels and decreased CD8＋ level in rats with oral ulcers. Conclusion Watermelon frost spray can improve symptoms of rats with oral ulcers and the possible mechanism is to reduce the level of the body＇s inflammatory response and corrective immune dysfunction to accelerate the healing.
出处
《中国现代医生》
2012年第12期9-10,共2页
China Modern Doctor
关键词
西瓜霜喷剂
口腔溃疡
症状
Watermelon frost spray
Oral ulcers
Symptom
