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P-选择素基因多态性及临床研究进展 被引量:4

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摘要 P-选择素(P-selectin,SELP)是一种相对分子质量为140 000的糖蛋白,属细胞粘附分子成员,可表达于活化的血小板及内皮细胞表面。其主要功能是介导白细胞、内皮细胞、血小板等细胞间的反应,在动、静脉血栓形成以及炎症和动脉粥样硬化的病理生理过程中发挥着重要作用[1]。
机构地区 福建省血液中心
出处 《福建医药杂志》 CAS 2011年第6期155-157,共3页 Fujian Medical Journal
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参考文献15

  • 1明凯华,李艳,夏尊恩,熊小泉.中国汉族人群P-选择素基因多态性的研究[J].临床检验杂志,2006,24(4):285-288. 被引量:10
  • 2Ay C,,Jungbauer LV,Sailer T,et al.High concentrations ofsoluble P-selectin are associated with risk of venous thromboem-bolism and the P-selectin Thr715 variant. Clinical Chemistry . 2007
  • 3Marie-Helene,Malaud E,Gayet O,et al.Mapping theepitope of a functional P-selectin monoclonal antibody(LYP20)to a short complement-like repeat(SCR 4)domain:use ofhu-man–mouse chimaera and homologue-replacement mutagene-sis. Biochemical Journal . 1998
  • 4Elmas E,Bugert P,Popp T,et al.The P-Selectin Gene Pol-ymorphism Val168Met:A Novel Risk Marker for the Occur-rence of Primary Ventricular Fibrillation During Acute Myocar-dial Infarction. Journal of Cardiovascular Electrophysiology . 2010
  • 5Martea JB,Lambert D,Herbeth B,et al.P-selectin Poly-morphisms’’influences on P-selectin serum concentrations andon their familial correlation:the STANISLAS family study. Journal of Thrombosis and Haemostasis . 2008
  • 6Carter AM,An agnosto PK,Mansfleld MW,et al.SolubleP-selectin levels.P-selcetin polymorphisms and cardio vasculardisease. ThrombHaemot . 2003
  • 7Robert YL,Nancy RC,Suzanne C,et al.Polymorphism inthe P-selectin and interleukin-4genes as determinants of stroke:apopulation-based,Prospective genetic analysis. HumanMolecular Genetics . 2004
  • 8Ay C,Jungbauer LV,Kaider A,et al.P-selectin gene haplotypes modulate soluble P-selectin concentrations and contribute to the risk of venous thromboembolism. Thrombosis and Haemostasis . 2008
  • 9Lee DS,Larson MG,Lunetta KL,et al.Clinical and genetic correlates of soluble P-selectin in the community. Journal of Thrombosis and Haemostasis . 2008
  • 10Barbaux SC,Blankenberg S,Rupprecht HJet al.Association be-tween P-seleetin Gene polymorphisms and soluble P-seleetin levelsand their relation to coronary artery disease.. Arteriosclerosis and Thrombosis . 2001

二级参考文献9

  • 1Barbaux C.Association between P-selectin gene polymorphisms and soluble P-selectin levels and their relation to coronary artery diseases[J].Arterioscler Thromb Vasc Biol[J],2001,21(10):1668-1673.
  • 2Stefan-Martin Herrmann,Sylvain Ricard,Viviane Nicaud1,et al.The P-selectin gene is highly polymorphic:reduced frequency of the Pro715 allele carriers in patients with myocardial infarction[J].Hum Mol Genet,1998,7(8):1277-1284.
  • 3Carter A M,Anagnostopoulou K,Mansfield M W,et al.Soluble P-selectin levels,P-selectin polymorphisms and cardiovascular disease[J].J Thromb Haemost,2003,1(8):1718-1723.
  • 4Wu G X,Li F G,Li P X,et al.Detection of plasma а-guanule menbrane protein(GMP-140) using radiolabeld monoclonal antibodies in thrombotic disease[J].Haemostasis,1993,23(2):121-128.
  • 5Nagashima M,Shin'Oka T,Nouert G,et al.Effects of a monoclonal antibody to P-selection on recovery of neonatal hearts after cold cardioplegic ischemia[J].Circulation,1998,98(19 suppl):Ⅱ391.
  • 6Zingarelli B,Salzman A L,Szabo C.Genetic disruption of poly (AD-Pribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecular in myocardial ischemia/reperfusion injury[J].Circ Res,1998,83(1):85-94.
  • 7Stenberg P E,McEver R P,Shuman M A,et al.A platelet alpha-granule membrane protein GMP-140 is expressed on the plasma membrane afteractivation[J].J Cell Biol,1985,101(3):880-886.
  • 8Polly M J,Phillips M L,Wayner E,et al.CD62 and endothelial cell leukocyte adhesion molecule 1 (ELAM21) recognize the same carbohydrate ligand,Sialyl-Lewis X[J].Proc Natl Acad Sci USA,1991,88(14):6224-6228.
  • 9李艳,黄宪章,张平安,李栋,刘军,李庚山.雌激素受体基因多态性与急性心肌梗死关系的研究[J].中华医学杂志,2001,81(7):389-392. 被引量:97

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