摘要
目的：观察枯草杆菌二联活菌对肝硬化患者内毒素血症的临床疗效。方法：将48例肝硬化患者随机分为治疗组和对照组，两组患者均采用常规的保肝治疗，治疗组家用枯草杆菌二联活菌（美常安）口服，疗程20天，应用鲎试验动态比浊法测定血浆内毒素（ET）、采用双抗体夹心ELISA法检测肿瘤坏死因子-α（TNF—α）及白细胞介素（IL）-6。结果：治疗组患者血浆内毒素、TNF—α和IL-6水平明显低于对照组。结论：枯草杆菌二联活菌（美常安）能明显降低肝硬化患者血浆ET、TNF—α和IL-6水平，对肝硬化内毒血症患者有很好的临床疗效，有助于肝硬化的治疗。
Objective To investigate the Clinical curative effects of Live Combined Bacillus Subtilis and Enterococcus Faecium in patients with liver cirrhosis and endotoxemia.Methods 48 patients with liver cirrhosis were randomly divided into treatment group and contral group（n=24）,control group received the liver protection and symptomatic treatment ,the treatment group were given the same treatment on the basis of Live Combined Bacillus Subtilis and Enterococcus Faecium Enteric-coated Capsules,Mter 20 days of treatment,the serum endotoxin was measured by limulus test,while the TNF- t~ and IL-6 were measured by double antibody ELISA.Resuhs：the levels of serum endotoxin, TNF- α and IL-6 in the patients of treatment group were lower than those of control group.Conclusion： Live Combined Bacillus Subtilis and Enteroeoccus Faecium could reduce the levels of serum endotoxin, TNF- α and IL-6 in patients with liver cirrhosis. So Live Combined Bacillus Subtilis and Enterococcus Faecium are effective In the clinical treatment.
关键词
肝硬化
枯草杆菌二联活菌
内毒素
liver cirrhosis
Live Combined Bacillus Subtilis and Enterococcus Faecium
endotoxin
