摘要
目的 研究硒、碘及两者联用对低碘大鼠甲状腺大小、血清甲状腺激素及促甲状腺激素释放激素(TRH)的影响。方法 给第 2代低碘鼠投于不同浓度的硒和碘 ,7周后 ,分别取甲状腺称重 ,并用放射免疫法测定血清中 T3、T4、FT3、FT4、TRH浓度及下丘脑 TRH含量。结果 与低碘组相比 ,补碘后甲状腺重量减轻 ,血中FT4、T4水平明显升高 ,血中 TRH浓度下降 ,下丘脑 TRH含量升高 ,补硒对甲状腺重量及血清 FT4、T4浓度也有一定的影响。结论 碘、硒及两者联用对低碘鼠甲状腺重量、血清 T4、FT4、TRH及下丘脑
Objective The study was aimed at investigating the influence of combined addition of selenium and iodine on thyroid weights,serum thyroid hormones and thyrotropin releasing hormone(TRH) of rats with iodine deficiency.Methods The second generation of rats with iodine deficiency was fed with different concentrations of selenium and iodine.After 7 weeks,the thyroid of rats were excised respectively.The concentrations of T 3、T 4、FT 3、FT 4、TRH in serum and TRH content in the hypothalamus were measured by RIA.Results Compared with iodine deficiency groups,the thyroid weights reduced;the level of FT 4,T 4 in the serum significantly increased;the concentration of TRH in serum reduced;the content of TRH in the hypothalamus increased in the rat group with iodine fed.The addition of selenium had certain influence on the thyroid weights and FT 4,T 4 in serum.Conclusions Combined addition of iodine and selenium plays important roles for changing of thyroid weights,T 4,FT 4,TRH in the serum and TRH concentration in the hypothalamus of rats with iodine deficiency. [
出处
《中国地方病学杂志》
CAS
CSCD
2000年第1期29-31,共3页
Chinese Jouranl of Endemiology
基金
国家自然科学基金!No19475 0 46
