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糖尿病视网膜病变患者血浆网膜素的变化及其相关因素 被引量：9

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摘要 目的探讨2型糖尿病(T2DM)及T2DM伴视网膜病变(DR)患者血浆网膜素水平变化及其与体重指数(BMI)、腰臀比(WHR)、血糖、血脂、血清空腹胰岛素(FINS)水平、肿瘤坏死因子α(TNF-α)等的关系。方法 62例T2DM,根据有无DR进一步分为伴DR和不伴(NDR)两组。同时选择健康成人28例作为正常对照组。采用酶联免疫法测定了空腹血浆网膜素水平,并分析血浆网膜素与BMI、WHR、血脂、血糖、血浆胰岛素水平及TNF-α等的关系。结果 T2DM病人血浆网膜素水平明显低于正常人(P<0.01),伴有DR组病人又明显低于无DR的病人(P<0.01)。血浆网膜素水平与BMI、WHR、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、TNF-α、糖化血红蛋白(HbA1c)、HOMA-IR、FINS和甘油三酯(TG)呈明显负相关(r=-0.415～-0.241,P<0.01或P<0.05),与高密度脂蛋白胆固醇(HDL-C)呈明显正相关(r=0.424,P<0.01)。HOMA-IR是影响T2DM患者血浆网膜素水平的独立相关因素,HOMA-IR和TNF-α是影响DR患者血浆网膜素水平的独立相关因素。结论血浆网膜素与糖脂代谢紊乱、炎症反应及肥胖引起的胰岛素抵抗有关,并可能在T2DM及DR的发生和发展中具有一定的作用。
作者 李健 余兰
机构地区 自贡市第一人民医院内分泌科 自贡市第一人民医院超声科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第8期1594-1595,共2页 Chinese Journal of Gerontology
关键词 网膜素 糖尿病视网膜病变 胰岛素抵抗
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献8

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二级参考文献8

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共引文献41

同被引文献68

  • 1耿芹,任建民,韩华,李莉,唐宽晓,侯新国,张秀英,洪云.DR与多种细胞因子及红细胞变形能力相关性的临床研究[J].山东大学学报（医学版）,2005,43(9):823-826. 被引量：1
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引证文献9

二级引证文献44

中国老年学杂志
2012年 第8期

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