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耐碳青霉烯类抗生素鲍曼不动杆菌中心静脉插管相关性血行感染危险因素分析 被引量：6

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摘要 目的了解我院重症医学科(ICU)临床分离的耐碳青霉烯类抗生素鲍曼不动杆菌(CRAb)所致的中心静脉插管相关性血行感染(CLABSI)的流行病学及耐药情况,以及CRAb致CLABSI的危险因素。方法选择2007年7月至2010年6月入住我院ICU的CRAb感染的患者,通过测定其对常用抗菌药物的敏感性,对CRAb的CLABSI患者进行回顾性研究。结果①ICU中CRAb所致的CLABSI的独立危险因素是分离出病原菌前14 d内接受碳青霉烯类抗生素治疗≥7 d(P=0.015,OR=6.112)、中心静脉插管留置时间≥14 d(P=0.023,OR=2.251)、进行外周血和导管标本培养前24 h APACHEⅡ评分≥20(P=0.041,OR=4.213)。②CRAb组菌株对大部分抗菌药物的耐药率大于90%,仅对头孢哌酮-舒巴坦、米诺环素有较高敏感性(耐药率为43.3%)。结论①分离出CRAb前14 d内接受碳青霉烯类抗生素治疗≥7 d、中心静脉插管留置时间≥14 d及进行外周血和导管标本培养前24 h APACHEⅡ评分≥20是ICU中CRAb所致的CLABSI的独立危险因素。②我院ICU临床分离的CRAb的耐药率较高,CRAb仅对头孢哌酮-舒巴坦、米诺环素保持较高敏感性。
作者 费东生 曹延会 孟祥林 南川川 赵鸣雁 徐海燕
机构地区 哈尔滨医科大学附属第一医院重症医学科 哈尔滨医科大学附属第一医院检验科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第8期1605-1608,共4页 Chinese Journal of Gerontology
关键词 鲍曼不动杆菌 碳青霉烯类耐药 中心静脉插管相关性血行感染 危险因素
分类号 R63 [医药卫生—外科学]
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参考文献9

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共引文献139

同被引文献93

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引证文献6

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中国老年学杂志
2012年 第8期

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