摘要
目的:观察不同中医证型复发性阿弗他溃疡(Recurrent Aphthous Ulcer,RAU)患者的免疫状况,探讨其中医证型与免疫的关系,为临床医师初步判断RAU患者免疫状况及合理用药提供参考。方法:97例RAU患者按中医辨证的方法分成胃火上炎型、阴虚火旺型、心脾积热型和脾肾阳虚型,分别检测其体液免疫及细胞免疫,对结果进行统计分析。结果:①胃火上炎型的RAU患者人数最多(44.3%)。②RAU患者外周血细胞免疫指标总体表现为体液免疫正常和细胞免疫的降低,其中CD3、CD4、和CD4/CD8水平分别降低86.60%、79.38%、和76.29%),③不同中医证型RAU患者组间比较显示:心脾积热型的CD3水平较其他三型低,组间差异具有统计学意义(P<0.05);脾肾阳虚型的CD3水平较其他三型高,组间差异具有统计学意义(P<0.05);阴虚火旺型的CD4、和CD4/CD8水平较胃火上炎型和脾肾阳虚型低,组间差异具有统计学意义(P<0.05);不同证型RAU患者的CD8水平差异无统计学意义(P>0.05)。结论:RAU患者的免疫状态以细胞免疫紊乱为主:RAU患者的中医证型和免疫存在一定的相关性。
Objective：To observe the correlation between RAU＇s Chinese medicine Syndrome Types and immunity,offering reference to clinician for prelimilary judgement of RAU＇s immunity and clinical treatment.Methods： 97 RAU patients were grouped under four syndromes： fire excess of stomach,yin-deficiency and fire-excess,accumulation of heart and spleen,spleen-kidney yang deficiency according to the method of Chinese medical differentiations.Penpheral blood parameters about immune function were examined in order to obtain the objective examination results of the immune status.The data was statistically analyzed.Result：Most of the patients went to fire excess of stomach syndrome（44.3%）.On the whole,CD3,CD4,and CD4/CD8 levels were decreased among the four syndromes（thc rate of decrease is respectively 86.60%4 79.38%,76.29%）,in the accumulation of heart and splenic syndrome,CD3 decreased significantly than the rest syndromes（p0.05）;In the spleen-kidney yang deficiency syndrome,CD3 increased significantly than the other three types（p0.05）;In the yin-deficiency and fire-excess,CD4 and CD4/CD8 decreased significantly than the fire excess of stomach and the spleen-kidney yang deficiency syndrome（p0.05）.No statistical difference had been reached so far among the different type of CD8（p0.05）.Conclusions： RAU patient＇s immune status is mainly of cell-based immune disorders;there is correlation between RAU＇s Chinese Medicine Differentiations and immunity to some degree.
出处
《激光杂志》
CAS
CSCD
北大核心
2012年第2期71-72,共2页
Laser Journal
关键词
复发性阿弗他溃疡
中医证型
免疫
recurrent aphthous ulcer（RAU）
Chinese medicine syndrome types
immunity
