注射用重组人Ⅱ型肿瘤坏死因子受体—抗体融合蛋白治疗类风湿关节炎并冠心病疗效观察被引量：1

下载PDF

导出

摘要目的观察注射用重组人Ⅱ型肿瘤坏死因子受体—抗体融合蛋白(益赛普)治疗类风湿关节炎并冠心病的临床疗效。方法将58例类风湿关节炎并冠心病患者随机分为观察组和对照组各29例。对照组给予常规药物治疗;观察组在对照组基础上皮下注射益赛普25mg,每周2次,连用3个月。治疗后观察2组临床疗效。结果观察组总有效率为82.8%高于对照组的55.2%,差异有统计学意义(P<0.05)。结论益赛普治疗类风湿关节炎并冠心病效果显著。

作者朱发术

机构地区湖北省建始县人民医院

出处《临床合理用药杂志》 2012年第13期89-89,共1页 Chinese Journal of Clinical Rational Drug Use

关键词注射用重组人Ⅱ型肿瘤坏死因子受体抗体融合蛋白类风湿关节炎冠心病

分类号 R593.22 [医药卫生—内科学]

引文网络
相关文献

参考文献5

1美国风湿病学会(ARA).类风湿性关节炎病期分类标准和关节功能分类标准[J]中华风湿病学杂志,1998(06):96.
2刘传慧,魏冬梅,张依山,吴卫新.云克对类风湿关节炎急性活动期的临床及实验室指标的影响[J].医药论坛杂志,2007,28(24):96-97. 被引量：5
3Raza K,Bucklcy CE,Smmon M. Treating very early rheumatoid arthritis[J].Best Practice and Research:Clinical Rheumatology,2006.849-863.
4吴智鸿,赵水平.类风湿关节炎与冠心病[J].中华风湿病学杂志,2004,8(11):688-690. 被引量：13
5张密林,高磊,戚国庆,崔冬生.冠心病血清同型半胱氨酸与血管内皮功能的关系研究[J].中国实用内科杂志,2006,26(12):1867-1869. 被引量：8

二级参考文献31

1杨岩,高岩,王君.血浆同型半胱氨酸与2型糖尿病视网膜病变相关性分析[J].中国实用内科杂志,2005,25(6):550-550. 被引量：9
2叶艳平,王辰,朱佐明,庞宝森,刘羽翔.肺血栓栓塞症患者血清同型半胱氨酸浓度叶酸与维生素B_(12)质量浓度变化及相关性研究[J].中国实用内科杂志,2005,25(11):1035-1036. 被引量：4
3王新华.云克治疗类风湿关节炎的临床研究[J].新疆医学,2006,36(6):106-107. 被引量：1
4Hurt-Camejo E,Paredes S,Masana L,et al.Elevated levels of small,low-density lipoprotein with high affinity for arterial matrix components in patients with rheumatoid arthritis:possible contribution of phospholipase A2 to this atherogenic profile.Arthritis
5Van Doornum S,McColl G,Wicks IP.Accelerated atherosclerosis:an extra articular feature of rheumatoid arthritis? Arthritis Rheum,2002,46:862-873.
6Chae CU,Lee RT,Rifai N,et al.Blood pressure and inflammation in apparently healthy men.Hypertension,2001,38:399-403.
7McEntegart A,Capell HA,Creran D,et al.Cardiovascular risk factors,including thrombotic variables,in a population with rheumatoid arthritis.Rheumatology,2001,40:640-644.
8Lazzerini PE,Capecchi PL,Bisogno S,et al.Reduction in plasma homocysteine level in patients with rheumatoid arthritis given pulsed glucocorticoid treatment.Ann Rheum Dis,2003,62:694-695.
9Bloom BJ,Miller LC,Tucker LB,et al.Soluble adhesion molecules in juvenile rheumatoid arthritis.J Rheumatol,1999,26:2044-2048.
10Veale DJ,Maple C,Kirk G,et al.Soluble cell adhesion molecules-P-selectin and ICAM-1,and disease activity in patients receiving sulphasalazine for active rheumatoid arthritis.Scand J Rheumatol,1998,27:296-299.