摘要
目的:了解超重、肥胖对2型糖尿病患者凝血及代谢紊乱的影响。方法:选择初诊为2型糖尿病的患者248例,根据人体质量指数(BMI)分为正常BMI对照组(95例)、超重组(87例)、肥胖组(66例),均测定血脂、血糖、空腹胰岛素等相关指标,计算胰岛素抵抗指数(HOMA-IR),并进行统计学处理。结果:与正常BMI对照组相比,超重组、肥胖组血浆纤维蛋白原(fg)[(3.37±0.55)g/L比(4.04±0.70)g/L比(5.20±0.69)g/L]、尿微量白蛋白(UMA)[(14.46±8.90)mg/g比(47.33±42.54)mg/g比(104.45±60.78)mg/g]、空腹血糖(FBG)[(7.15±0.97)mmol/L比(8.84±1.81)mmol/L比(10.06±2.28)mmol/L]、空腹胰岛素(FINS)[(10.09±8.21)IU/ml比(14.33±15.55)IU/ml比(19.69±10.86)IU/ml]、HOMA-IR[(3.19±2.59)比(5.51±5.38)比(8.48±4.62)]及血甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)水平均明显升高,且随肥胖程度的增加而呈上升趋势,而血浆凝血酶原时间(PPT)[(13.33±0.69)s比(12.74±0.69)s比(11.43±0.53)s]、血浆活化部分凝血活酶时间(APTT)[(37.32±2.31)s比(36.55±2.41)s比(34.61±1.53)s]、HDL-C[(1.54±1.12)mmol/L比(1.27±0.41)mmol/L比(1.09±0.28)mmol/L]水平均明显降低,且随肥胖程度的加深而呈下降趋势(P均<0.05)。结论:超重及肥胖加重2型糖尿病凝血功能及代谢障碍,并加重胰岛素抵抗的程度,且此异常随肥胖程度的加深而更加严重。
Objective：To study influence of overweight and obesity on blood coagulation and metabolic disorders in patients with type 2 diabetes mellitus（T2DM）.Methods： total of 248 preliminary diagnosed T2DM patients were selected.According to body mass index（BMI）,they were divided into normal BMI control group（n=95）,overweight group（n=87） and obesity group（n=66）.Blood lipids,blood glucose and fasting insulin（FINS） were measured in all patients and homeostasis model-insulin resistance index（HOMA-IR） was calculated then.Statistical analysis was performed.Results：Compared with normal BMI control group,there were significant increase in fibrinogen [（3.37±0.55） g/L vs.（4.04±0.70） g/L vs.（5.20±0.69） g/L],urine microalbumin [（14.46±8.90） mg/g vs.（47.33±42.54） mg/g vs.（104.45±60.78） mg/g],fasting blood glucose [（7.15±0.97） mmol/L vs.（8.84±1.81） mmol/L vs.（10.06±2.28） mmol/L],FINS [（10.09±8.21） IU/ml vs.（14.33±15.55） IU/ml vs.（19.69±10.86） IU/ml],HOMA-IR[（3.19±2.59） vs.（5.51±5.38） vs.（8.48±4.62）],TG,TC and LDL-C levels in overweight group and obesity group,and the more BMI patients were,the higher these indicators were;There were significant decrease in plasma prothrombin time [（13.33±0.69）s vs.（12.74±0.69）s vs.（11.43±0.53）s],activated partial thromboplastin time [（37.32±2.31）s vs.（36.55±2.41）s vs.（34.61±1.53）s] and HDL-C [（1.54±1.12） mmol/L vs.（1.27±0.41） mmol/L vs.（1.09±0.28） mmol/L] in overweight group and obesity group（P0.05 all）.Conclusion：Overweight and obesity aggravate coagulation and metabolic disorders in patients with type 2 diabetes mellitus.It also aggravates degree of insulin resistance,the more BMI patients are,the more serious they are.
出处
《心血管康复医学杂志》
CAS
2012年第2期125-129,共5页
Chinese Journal of Cardiovascular Rehabilitation Medicine
基金
Scientific and technological project in Liaoning Province(2011225052-2011020216-428)~~
关键词
糖尿病
2型
肥胖症
凝血酶原
高脂血症
Diabetes mellitus
type 2
Obesity
Blood lipid
Hyperlipidemia
